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Titolo:
HYPOXIC EXPOSURE TIME DEPENDENTLY MODULATES ENDOTHELIN-INDUCED CONTRACTION OF PULMONARY-ARTERY SMOOTH-MUSCLE
Autore:
BIALECKI RA; FISHER CS; MURDOCH WW; BARTHLOW HG; STOW RB; MALLAMACI M; RUMSEY W;
Indirizzi:
ZENECA INC,ZENECA PHARMACEUT,RESP INFLAMMATORY & NEUROL RES SECT,BMRL-233,1800 CONCORD PIKE WILMINGTON DE 19850
Titolo Testata:
American journal of physiology. Lung cellular and molecular physiology
fascicolo: 4, volume: 18, anno: 1998,
pagine: 552 - 559
SICI:
1040-0605(1998)18:4<552:HETDME>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOCONSTRICTOR PEPTIDE; RECEPTOR SUBTYPES; CELLS; SARAFOTOXIN; CHANNELS; BINDING;
Keywords:
AORTA; HYPOXIA; SARAFOTOXIN S6B; SARAFOTOXIN S6C; PULMONARY HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Bialecki et al., "HYPOXIC EXPOSURE TIME DEPENDENTLY MODULATES ENDOTHELIN-INDUCED CONTRACTION OF PULMONARY-ARTERY SMOOTH-MUSCLE", American journal of physiology. Lung cellular and molecular physiology, 18(4), 1998, pp. 552-559

Abstract

Endothelins (ETs) have been implicated in the pathogenesis of hypoxia-induced pulmonary hypertension. We determined whether hypoxic exposure of rats (10% O-2-90% N-2, 1 atm, 1-48 days) altered contraction to ET in isolated segments of endothelium-denuded extralobar branch pulmonary artery (PA) and aorta. Hypoxic exposure increased hematocrit, right ventricular hypertrophy, and ET-1 plasma concentration. Hypoxia alsocaused a sustained decrease in PA but not in aorta sensitivity to ET-1. In comparison, hypoxic exposure throughout 12 days decreased time dependently the maximum contraction of PA to ET-1, BaCl2, and KCl. The hypoxia-induced decrease in maximum contraction of PA to ET-1 returnedtoward normal levels by 21 days and approximated control levels by 48days. After 14 days of hypoxia, right ventricular hypertrophy correlated with decreased sensitivity of PA to ET-1. After 21 days of hypoxia, PA sensitivity to ET-2 and ET-3 was decreased, and sarafotoxin S6c-induced contraction was abolished. In conclusion, hypoxic exposure timedependently modulates the responsiveness of PA smooth muscle to ETs, BaCl2, and KCl. The hypoxia-induced changes in tissue responsiveness to ET-1 may be associated with increased plasma concentrations of this peptide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:09:55