Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ESTIMATION OF OXIDATIVE DNA-DAMAGE IN MAN FROM URINARY-EXCRETION OF REPAIR PRODUCTS
Autore:
LOFT S; POULSEN HE;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,DEPT PHARMACOL,ROOM 18-5-32 DK-2200 COPENHAGEN N DENMARK RIGSHOSP,DEPT CLIN PHARMACOL DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Acta Biochimica Polonica
fascicolo: 1, volume: 45, anno: 1998,
pagine: 133 - 144
SICI:
0001-527X(1998)45:1<133:EOODIM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; STABLE-ISOTOPE DILUTION; BIOLOGICAL MARKER; THYMIDINE GLYCOL; OXYGEN RADICALS; THYMINE GLYCOL; NUCLEAR-DNA; HUMAN-CELLS; RAT URINE; 8-HYDROXYDEOXYGUANOSINE;
Keywords:
BIOMARKERS; OXIDATIVE DNA DAMAGE; 8-OXO-2'-DEOXYGUANOSINE; CANCER; AGING; ANTIOXIDANTS; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
S. Loft e H.E. Poulsen, "ESTIMATION OF OXIDATIVE DNA-DAMAGE IN MAN FROM URINARY-EXCRETION OF REPAIR PRODUCTS", Acta Biochimica Polonica, 45(1), 1998, pp. 133-144

Abstract

DNA is constantly damaged and repaired in living cells. The repair products of the oxidative DNA lesions, i.e. oxidised nucleosides and bases, are poor substrates for the enzymes involved in nucleotide synthesis, are fairly water soluble, and generally excreted into the urine without further metabolism. Among the possible products, 8-oxo-2'-deoxyguanosine, 8-oxoguanine, thymine glycol, thymidine glycol and, 5-hydroxymethyluracil have so far been identified in urine. It should be emphasised that the excretion of the repair products in urine represents the average rate of damage in the total body whereas the level of oxidised bases in nuclear DNA is a concentration measurement in that specific tissue/cells in the moment of sampling. The rate of oxidative DNA modifications has been studied in humans by means of the repair productsas urinary biomarkers, particularly with respect to 8-oxo-2'-deoxyguanosine. The data obtained so far indicate that the important determinants of the oxidative damage rate include tobacco smoking, oxygen consumption and some inflammatory diseases whereas diet composition, energyrestriction and antioxidant supplements have but a minimal influence,possibly with the exception of yet unidentified phytochemicals, e.g. from cruciferous vegetables.The data are consistent with the experimentally based notion that oxidative DNA damage is an important mutagenicand apparently carcinogenic factor. However, the proof of a causal relationship in humans is still warranted. In the future the use of biomarkers may provide this evidence and allow further investigations on the qualitative and quantitative importance of oxidative DNA modification and carcinogenesis in man, as well as elucidate possible preventivemeasures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:11:19