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Titolo:
INTRAMURAL INJECTION OF BIODEGRADABLE MICROSPHERES AS A LOCAL DRUG-DELIVERY SYSTEM TO INHIBIT NEOINTIMAL THICKENING IN A RABBIT MODEL OF BALLOON ANGIOPLASTY
Autore:
VALERO F; HAMON M; FOURNIER C; MEURICE T; FLAUTRE B; VANBELLE E; LABLANCHE JM; GOSSELIN B; BAUTERS C; BERTRAND M;
Indirizzi:
HOP CARDIOL,SERV CARDIOL B & HEMODYNAM,BLVD PROF J LECLERCQ F-59037 LILLE FRANCE UNIV LILLE LILLE FRANCE CHRU LILLE LILLE FRANCE
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 31, anno: 1998,
pagine: 513 - 519
SICI:
0160-2446(1998)31:4<513:IIOBMA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CORONARY ANGIOPLASTY; VASCULAR INJURY; ARTERIAL INJURY; RESTENOSIS; PREVENTION; GLUCOCORTICOIDS; PROLIFERATION; CATHETERS; HEPARIN;
Keywords:
ANGIOPLASTY; RABBIT; RESTENOSIS; HYDROCORTISONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
F. Valero et al., "INTRAMURAL INJECTION OF BIODEGRADABLE MICROSPHERES AS A LOCAL DRUG-DELIVERY SYSTEM TO INHIBIT NEOINTIMAL THICKENING IN A RABBIT MODEL OF BALLOON ANGIOPLASTY", Journal of cardiovascular pharmacology, 31(4), 1998, pp. 513-519

Abstract

Restenosis remains the major limitation of coronary angioplasty. The objective of this study was to develop microspheres able to be delivered at the angioplasty site for long-term drug release and to test their effects in a model of balloon angioplasty. Polylactic-co-glycolide acid microspheres (5-10 mu m in diameter) were prepared by using an oil-in-water emulsion-solvent evaporation method. In vitro experiments with hydrocortisone-loaded microspheres revealed a hydrocortisone release for 4 weeks. We studied the in vivo effect of injection of microspheres into the arterial wall of New Zealand White rabbits by using a perforated balloon. Deep penetration of microspheres in the arterial wallwas documented immediately after angioplasty. Intimal hyperplasia wasassessed in iliac arteries 4 weeks after angioplasty. The morphometric analysis was performed in four groups of animals; the first group was subjected only to conventional angioplasty (control, n = 10), whereas the other three groups after conventional angioplasty were received perforated balloon angioplasty with saline (n = 10), microspheres (n =10), or hydrocortisone-loaded microspheres (n = 7). Intramural injection of saline did not induce greater intimal hyperplasia compared withcontrol (0.17 +/- 0.03 vs. 0.18 +/- 0.03 mm(2), respectively). Microspheres injection was associated with a trend toward a greater degree of intimal hyperplasia that did not reach statistical significance. Hydrocortisone-loaded microspheres were associated with a significant reduction in intimal hyperplasia compared with unloaded microspheres (0.16 +/- 0.02 vs. 0.26 +/- 0.03 mm(2), respectively). The polylactic-co-glycolide acid microspheres are well tolerated, easily injected into the arterial wall, and the increase of intimal hyperplasia is easily inhibited by release of hydrocortisone for 4 weeks after initial injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:38:59