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Titolo:
UL-FS-49 (ZATEBRADINE) DOES NOT AFFECT ARTERIAL BAROREFLEX IN CONSCIOUS NORMAL OR AORTIC-CONSTRICTED RATS
Autore:
SAKAMOTO M; SIRI FM; SOLOMON SB; TANIMOTO H; YELLIN EL;
Indirizzi:
MT SINAI SCH MED,BRONX VA MED CTR,GMR 4F-04,130 W KINGSBRIDGE RD BRONX NY 10468 KUMAMOTO UNIV,SCH MED,DEPT ANESTHESIOL KUMAMOTO 860 JAPAN ALBERT EINSTEIN COLL MED,DEPT CARDIOPHYSIOL & BIOPHYS BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT CARDIOVASC SURG BRONX NY 10467
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 31, anno: 1998,
pagine: 488 - 492
SICI:
0160-2446(1998)31:4<488:U(DNAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG CARDIAC PREPARATIONS; SINOATRIAL NODE CELLS; BRADYCARDIAC AGENT; ANESTHETIZED DOGS; PACEMAKER CURRENT; ZENECA ZD7288; HEART-FAILURE; CURRENT I(F); UL-FS-49; HYPERTROPHY;
Keywords:
UL-FS 49; ZATEBRADINE; BRADYCARDIA; ARTERIAL BAROREFLEX; SYSTEMIC HYPERTENSION; LEFT VENTRICULAR HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Sakamoto et al., "UL-FS-49 (ZATEBRADINE) DOES NOT AFFECT ARTERIAL BAROREFLEX IN CONSCIOUS NORMAL OR AORTIC-CONSTRICTED RATS", Journal of cardiovascular pharmacology, 31(4), 1998, pp. 488-492

Abstract

Heart-rate reduction is an important element of patient management during cardiac bypass surgery and in therapeutic measures for combating ischemia and relieving pain in patients with angina. UL-FS 49 is a novel bradycardic agent that purportedly acts solely on the sinoatrial node without potentially deleterious effects on arterial pressure and cardiac inotropism. However, little is known about influences of this agent on neuronal tissue and cardiovascular reflexes. Moreover, left ventricular hypertrophy, which often accompanies cardiovascular disease, is known to attenuate the arterial baroreflex and could have effects interactive with those of UL-FS 49. In this study, the effects of UL-FS49 on the arterial baroreflex were tested in normal rats (N), rats with left ventricular hypertrophy 14 days after abdominal aortic constriction (AC), and sham-operated controls (SH). Arterial baroreflex sensitivity (BRS) was estimated as the slope of the relation between mean arterial pressure (independent variable) and the RR interval (dependentvariable). At the time of study, the AC group had significantly greater mean arterial pressure than either SH or N (159 +/- 2, 122 +/- 3, and 124 +/- 3 mm Hg, respectively; mean +/- SEM, p < 0.01) and significantly greater left ventricular mass to body mass ratio than did SH (3.73 +/- 0.11, 2.33 +/- 0.11 mg/g; p < 0.01). As expected, BRS was significantly depressed in AC, compared with either SH or N (0.52 +/- 0.16,1.48 +/- 0.12, 1.69 +/- 0.25 ms/mm Hg, respectively; p < 0.01). Despite its potent dose-dependent bradycardic effects in all three groups, UL-FS 49 did not affect BRS significantly in any group. These results show that the arterial baroreflex is largely unaffected by UL-FS 49 inboth normal rats and rats with systemic hypertension and left ventricular hypertrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:26:19