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Titolo:
CENTRAL ACTIONS OF ADRENOMEDULLIN ON CARDIOVASCULAR PARAMETERS AND SYMPATHETIC OUTFLOW IN CONSCIOUS RATS
Autore:
SAITA M; SHIMOKAWA A; KUNITAKE T; KATO K; HANAMORI T; KITAMURA K; ETO T; KANNAN H;
Indirizzi:
MIYAZAKI MED COLL,DEPT PHYSIOL 1,5200 KIHARA MIYAZAKI 8891692 JAPAN MIYAZAKI MED COLL,DEPT PHYSIOL 1 MIYAZAKI 8891692 JAPAN MIYAZAKI MED COLL,DEPT INTERNAL MED MIYAZAKI 8891692 JAPAN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 43, anno: 1998,
pagine: 979 - 984
SICI:
0363-6119(1998)43:4<979:CAOAOC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SMOOTH-MUSCLE CELLS; HYPOTENSIVE PEPTIDE; VASODILATORY PEPTIDE; NERVOUS-SYSTEM; CALCITONIN; RECEPTOR; CLONING; PLASMA; STIMULATION;
Keywords:
RENAL SYMPATHETIC NERVE ACTIVITY; SINOAORTIC-DENERVATED RATS; RECEPTOR ANTAGONISTS; NEUROPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Saita et al., "CENTRAL ACTIONS OF ADRENOMEDULLIN ON CARDIOVASCULAR PARAMETERS AND SYMPATHETIC OUTFLOW IN CONSCIOUS RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 43(4), 1998, pp. 979-984

Abstract

Adrenomedullin (ADM) is reported to be a peripherally acting hypotensive peptide, but its central actions are unclear. We investigated the effects of centrally administered ADM on blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA) in conscious ratsand sinoaortic-denervated (SAD) rats. We also investigated the receptors interacting with ADM using two putative antagonists. Intracerebroventricular administration of ADM in doses of 0.1 and 0.5 nmol/kg caused tachycardia and early inhibition of RSNA. Central ADM (1.0 nmol/kg) induced hypertension, tachycardia, and a decrease followed by an increase in RSNA. In SAD rats, increases in BP, HR, and RSNA at the late phase were enhanced by central ADM (1.0 nmol/kg), whereas the early decrease in RSNA remained. Thus the inhibition of RSNA via central ADM maybe unrelated to the arterial baroreceptor reflex. Pretreatment with antagonists human calcitonin gene-related peptide-(8-37) and human ADM-(22-52) significantly suppressed the central actions of ADM. The findings suggest that ADM is involved as a neuropeptide in the receptor-mediated central regulation of the cardiovascular system and RSNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 02:02:15