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Titolo:
DOPAMINE AND N-METHYL-D-ASPARTATE RECEPTOR INTERACTIONS IN THE NEOSTRIATUM
Autore:
CEPEDA C; LEVINE MS;
Indirizzi:
UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,760 WESTWOOD PLAZA LOSANGELES CA 90024 UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR LOS ANGELES CA 90024
Titolo Testata:
Developmental neuroscience
fascicolo: 1, volume: 20, anno: 1998,
pagine: 1 - 18
SICI:
0378-5866(1998)20:1<1:DANRII>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; EXCITATORY SYNAPTIC TRANSMISSION; LONG-TERM DEPRESSION; RETINAL HORIZONTAL CELLS; CAUDATE-NUCLEUS NEURONS; PROTEIN KINASE-A; BASAL GANGLIA; CALCIUM CHANNELS; GENE-EXPRESSION; SPINY NEURONS;
Keywords:
DOPAMINE; ELECTROPHYSIOLOGY; NEOSTRIATUM; N-METHYL-D-ASPARTATE; RECEPTOR INTERACTIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
222
Recensione:
Indirizzi per estratti:
Citazione:
C. Cepeda e M.S. Levine, "DOPAMINE AND N-METHYL-D-ASPARTATE RECEPTOR INTERACTIONS IN THE NEOSTRIATUM", Developmental neuroscience, 20(1), 1998, pp. 1-18

Abstract

This review examines dopamine (DA) and glutamate receptor interactions in the neostriatum (NS) primarily from a neurophysiological perspective. Historically, a clear understanding of the function of DA. in theNS has been difficult because it was considered a classical neurotransmitter with either excitatory or inhibitory actions and because many of the data were obtained by use of varying methodologies. When DA is considered a neuromodulator whose role is to alter how NS cells respond to glutamatergic inputs, many of its actions can be accounted for and predicted with great accuracy within a model of receptor subtype. Inthis model, DA via activation of D1 receptors potentiates responses mediated by activation of N-methyl-D-aspartate (NMDA) receptors. DA viaactivation of D2 receptors attenuates responses mediated by activation of non-NMDA receptors. Outcomes of combinations of NMDA and D2 and non-NMDA and DI receptors are not as predictable. The mechanisms underlying the D1-NMDA receptor interactions appear to involve alterations in cell excitability mediated by activation of Ca2+ conductances and/orphosphorylation of NMDA receptors. Less is known about mechanisms underlying the D2-non-NMDA receptor interaction. The functional implications of this model in setting membrane potentials, signal-to-noise ratio, plasticity and excitotoxicity are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:18:13