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Titolo:
CLINICAL RELEVANCE OF TL-201-CHLORIDE SPET IN THE DIFFERENTIAL-DIAGNOSIS OF BRAIN-TUMORS
Autore:
STAFFEN W; HONDL N; TRINKA E; IGLSEDER B; UNTERRAINER J; LADURNER G;
Indirizzi:
LANDESNERVENKLIN SALZBURG,DEPT NEUROL,IGNAZ HARRER STR 79 A-5020 SALZBURG AUSTRIA
Titolo Testata:
Nuclear medicine communications
fascicolo: 4, volume: 19, anno: 1998,
pagine: 335 - 340
SICI:
0143-3636(1998)19:4<335:CROTSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON-EMISSION TOMOGRAPHY; TL-201 SPECT; FOLLOW-UP; TUMORS; GLIOMA; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W. Staffen et al., "CLINICAL RELEVANCE OF TL-201-CHLORIDE SPET IN THE DIFFERENTIAL-DIAGNOSIS OF BRAIN-TUMORS", Nuclear medicine communications, 19(4), 1998, pp. 335-340

Abstract

Magnetic resonance imaging (MRI) and computed tomography (CT) may notbe reliable in the differential diagnosis of tumour necrosis, scar and recurrent tumour. We compared Tl-201-chloride SPET with CT and MRI for the differential diagnosis of these cerebral lesions. Brain SPET was performed in 40 patients after the intravenous injection of Tl-201-chloride. All 40 patients also had a CT or MRI scan, and a histologicaldiagnosis was available for 27 of the patients. For each patient, theratio of counts in the lesion region of interest (ROI) to counts in the contralateral ROI was calculated and found to be between 0.58 and 9.60. The ratios for high-grade gliomas, metastases and meningiomas were high (> 2.7), especially in tumours with good vacularization. A low ratio (< 1.7) was noted in patients with low-grade astrocytoma, necrosis or ischaemic lesions. There were two exceptional cases of ischaemiclesions in the luxury perfusion stage (ratios of 3.61 and 3.87), as verified by HMPAO-SPET. We found that Tl-201-chloride SPET helps to differentiate between malignant tumours, poorly vascularized benign lesions and necrosis. Differentiation between low-grade astrocytoma and non-malignant lesions was not possible, but there was a trend towards differentiating between low-grade astrocytoma and ischaemic infarction. The timing of the investigation is important to avoid false-positive results in hyperperfused ischaemic tissue. ((C) 1998 Chapman & Hall Ltd.).

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Documento generato il 05/04/20 alle ore 07:11:46