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Titolo:
ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY OF SOME (2-BENZOXAZOLONE-3-YL AND 2-BENZOTHIAZOLONE-3-YL)ACETIC ACID-DERIVATIVES
Autore:
DOGRUER DS; UNLU S; SAHIN MF; YESILADA E;
Indirizzi:
GAZI UNIV,FAC PHARM,DEPT PHARMACEUT CHEM TR-06330 ANKARA TURKEY GAZI UNIV,FAC PHARM,DEPT PHARMACEUT CHEM TR-06330 ANKARA TURKEY GAZI UNIV,FAC PHARM,DEPT PHARMACOGNOSY TR-06330 ANKARA TURKEY
Titolo Testata:
Il Farmaco
fascicolo: 1, volume: 53, anno: 1998,
pagine: 80 - 84
SICI:
0014-827X(1998)53:1<80:AAAAOS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Keywords:
ANTINOCICEPTIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; BENZOXAZOLINONE DERIVATIVES; BENZOTHIAZOLINONE DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Dogruer et al., "ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY OF SOME (2-BENZOXAZOLONE-3-YL AND 2-BENZOTHIAZOLONE-3-YL)ACETIC ACID-DERIVATIVES", Il Farmaco, 53(1), 1998, pp. 80-84

Abstract

Sixteen (2-benzothiazolone-3-yl and 2-benzoxazolone-3-yl)acetic acid derivatives 5 have been tested for anti-nociceptive and antiinflammatory activity in this study. 4-[2-(6-Benzoyl-2-benzoxazolone-3-yl)acetyl] morpholine [6-(2-chloro-benzoyl)-2-benzoxazolone-3-yl]acetyl} -morpholine (5d), -(5-chloro-2-benzoxazolone-3-yl)acetyl]pyrrolidine (5f), methyl (6-methyl-2-benzoxazolone-3-yl)acetate (5k) and N,N-diethyl-2-(2-benzothiazolone-3-yl)acetamide (5m) have shown more potent anti-nociceptive activity than others. Among these compounds, 5c, 5d and 5m haveexhibited good anti-inflammatory activity, with 5f, and to a lesser extent, the other molecules displaying some toxic potential. (C) 1998 Elsevier Science S.A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:52:26