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Titolo:
DOPAMINE D2-RECEPTOR DENSITY IN HUMANS AS ASSESSED WITH SPET AND THE NEW HIGH-AFFINITY LIGAND I-123 NCQ298 - A PILOT-STUDY
Autore:
RYDING E; TUNINGER E; OHLSSON T; SJOHOLM H; FRECCEROROSMAN K; LEVANDER S; ROSEN I;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN NEUROPHYSIOL S-22185 LUND SWEDEN
Titolo Testata:
Nuclear medicine communications
fascicolo: 3, volume: 19, anno: 1998,
pagine: 263 - 270
SICI:
0143-3636(1998)19:3<263:DDDIHA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; RECEPTORS; D-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
E. Ryding et al., "DOPAMINE D2-RECEPTOR DENSITY IN HUMANS AS ASSESSED WITH SPET AND THE NEW HIGH-AFFINITY LIGAND I-123 NCQ298 - A PILOT-STUDY", Nuclear medicine communications, 19(3), 1998, pp. 263-270

Abstract

Astra (S)-3-[I-123] -5,6-dimethoxyl-N-[(1-ethyl-2-pyrrolidinyl)methyl] -salicylamide (I-123-NCQ298) is a new high-affinity D2-receptor ligand for use in single photon emission tomography (SPET) studies. We have studied the biodistribution and absorbed radiation dose of I-123-NCQ298 in humans. The mean effective dose for adults was 0.055 mSv MBq-1. Brain uptake and clearance was measured with a head dedicated SPET camera. 123 I-NCQ298 showed specific uptake in the basal ganglia with a low clearance rate (time constant of 9-34 h). The extrastriatal binding was variable (average 30%, maximum 60% of that in the basal ganglia at 1 h), but with a clearance rate twice that of the basal ganglia. The fairly high level of extrastriatal binding precluded the use of a quotient between the basal ganglia and cerebellum-to-frontal cortex I-123-NCQ298 concentration as a measure for basal ganglia D2-receptor density. Chronic schizophrenic patients treated with conventional neuroleptics had a decreased affinity for I-123-NCQ298 in the basal ganglia inthe range 10-60% of the median value for the control, untreated subjects. ((C) 1998 Chapman & Hall Ltd.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:57:31