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Titolo:
THE YEAST GENE YJR025C ENCODES A 3-HYDROXYANTHRANILIC ACID DIOXYGENASE AND IS INVOLVED IN NICOTINIC-ACID BIOSYNTHESIS
Autore:
KUCHARCZYK R; ZAGULSKI M; RYTKA J; HERBERT CJ;
Indirizzi:
UNIV PARIS 06,CTR GENET MOL,CNRS,LAB PROPRE F-91198 GIF SUR YVETTE FRANCE UNIV PARIS 06,CTR GENET MOL,CNRS,LAB PROPRE F-91198 GIF SUR YVETTE FRANCE POLISH NATL ACAD SCI,INST BIOCHEM & BIOPHYS PL-02106 WARSAW POLAND
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 424, anno: 1998,
pagine: 127 - 130
SICI:
0014-5793(1998)424:3<127:TYGYEA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Keywords:
3-HYDROXYANTHRANILIC ACID DIOXYGENASE; KYNURENINE PATHWAY; NICOTINIC ACID BIOSYNTHESIS; TRYPTOPHAN DEGRADATION; SACCHAROMYCES CEREVISIAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R. Kucharczyk et al., "THE YEAST GENE YJR025C ENCODES A 3-HYDROXYANTHRANILIC ACID DIOXYGENASE AND IS INVOLVED IN NICOTINIC-ACID BIOSYNTHESIS", FEBS letters, 424(3), 1998, pp. 127-130

Abstract

We have deleted the yeast gene YJR025c and shown that this leads to an auxotrophy for nicotinic acid. The deduced protein sequence of the gene product is homologous to the human 3-hydroxyanthranilic acid dioxygenase (EC 1.13.11.6) which is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid. In cell-free extracts the 3-hydroxyanthranilic acid dioxygenase activity is proportional to the copy number of the YJR025c gene. As YJR025c encodes the yeast 3-hydroxyanthranilic acid dioxygenase, we have named this gene BNA1 for biosynthesis of nicotinic acid. (C) 1998 Federation ofEuropean Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:53:13