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Titolo:
LAMOTRIGINE IN RETT-SYNDROME - TREATMENT EXPERIENCE FROM A PILOT-STUDY
Autore:
STENBOM Y; TONNBY B; HAGBERG B;
Indirizzi:
HUDDINGE UNIV HOSP,DEPT CHILD & ADOLESCENT PSYCHIAT S-14186 HUDDINGE SWEDEN HALMSTAD CENT CTY HOSP,DEPT PEDIAT S-30185 HALMSTAD SWEDEN EAST HOSP,DEPT PEDIAT 2 S-41685 GOTHENBURG SWEDEN
Titolo Testata:
European child & adolescent psychiatry
fascicolo: 1, volume: 7, anno: 1998,
pagine: 49 - 52
SICI:
1018-8827(1998)7:1<49:LIR-TE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPILEPSY; CHILDREN;
Keywords:
RETT SYNDROME; LAMOTRIGINE; EPILEPSY; MOTOR FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
Y. Stenbom et al., "LAMOTRIGINE IN RETT-SYNDROME - TREATMENT EXPERIENCE FROM A PILOT-STUDY", European child & adolescent psychiatry, 7(1), 1998, pp. 49-52

Abstract

This open pilot study was performed to evaluate the effect of Lamotrigine (LTG) in girls with Rett syndrome (RS) regarding seizure frequency, effect on gross motor dyspraxia and safety. Twelve girls with either the classical form of RS or the milder form fruste variants were included. The effect on epilepsy was evaluated as seizure frequency, motor performance (video comparison) and safety at clinical check up. The dosage of LTG was individualized and related to concomitant anti-epileptic drugs. Two of three girls with epilepsy responded relatively wellto treatment, and for one of them even bad tantrums disappeared. LTG was useful in another four girls who became happier, more alert, more able to concentrate, and improved in contacting. Only mild adverse reactions as rash and tremor were seen. It is concluded that LTG could beworth trying as an adjunct in girls with RS, being aware of possible adverse reactions and no effect at all.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:17:24