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Titolo:
MITOGEN-ACTIVATED PROTEIN-KINASES ACTIVATED BY LIPOPOLYSACCHARIDE ANDBETA-AMYLOID IN CULTURED RAT MICROGLIA
Autore:
PYO H; JOU I; JUNG S; HONG S; JOE E;
Indirizzi:
AJOU UNIV,SCH MED,DEPT PHARMACOL,PALDAL GU,SAN 5 WONCHEON DONG SUWON 442749 KYUNGGI DO SOUTH KOREA AJOU UNIV,SCH MED,DEPT PHARMACOL,PALDAL GU SUWON 442749 KYUNGGI DO SOUTH KOREA
Titolo Testata:
NeuroReport
fascicolo: 5, volume: 9, anno: 1998,
pagine: 871 - 874
SICI:
0959-4965(1998)9:5<871:MPABLA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE MACROPHAGES; MAMMALIAN BRAIN; STIMULATION; INDUCTION; CLONING;
Keywords:
BETA-AMYLOID; LIPOPOLYSACCHARIDE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Pyo et al., "MITOGEN-ACTIVATED PROTEIN-KINASES ACTIVATED BY LIPOPOLYSACCHARIDE ANDBETA-AMYLOID IN CULTURED RAT MICROGLIA", NeuroReport, 9(5), 1998, pp. 871-874

Abstract

To test whether mitogen-activated protein kinases (MAPKs) are involved in microglial activation, pure microglia prepared from 1- to 3-day-old rat brains were activated with either 100 ng/ml lipopolysaccharide (LPS) or 5 nM synthetic beta-amyloid (A beta) (25-35). The patterns ofMAPK activation following LPS and A beta treatment were very similar. Three MAPK subtypes, p38, extracellular signal-regulated kinase (ERK)and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) were activated within 15 min and the activities of p38 and ERK were rapidly reduced to background level within 30 min while that of JNK was maintained for over 1 h. Both inhibitors of p38 (SB203580) and ERK pathway (PD098059) reduced LPS-induced nitric oxide (NO) release and A beta-induced tumor necrosis factor-alpha (TNF-alpha) release. Furthermore, co-treatment of SB203580 and PD098059 additively reduced NO and TNF-alpha release. These results suggest that MAPK, at least p38 and ERK, mediate LPS-, and A beta-induced microglial activation. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 23:24:38