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Titolo:
QUANTITATIVE ESTIMATION OF I-123 IOMAZENIL RECEPTOR-BINDING IN TEMPORAL-LOBE EPILEPSIES USING 2 SPECT ACQUISITIONS - COMPARISON WITH THE REGIONAL CEREBRAL BLOOD-FLOW AND A COMPARTMENT MODEL
Autore:
VENZ S; HIERHOLZER J; CORDES M; STRAUB HB; KESKE U; MEENCKE HJ; EICHSTADT H; FELIX R;
Indirizzi:
HUMBOLDT UNIV,KLINIKUM RUDOLF VIRCHOW,STRAHLENKLIN & POLIKLIN,AUGUSTENBURGER PL 1,CHARITE CAMPUS D-13353 BERLIN GERMANY HUMBOLDT UNIV,KLINIKUM RUDOLF VIRCHOW,NEUROL KLIN & POLIKLIN D-13353 BERLIN GERMANY
Titolo Testata:
Nuklearmedizin
fascicolo: 2, volume: 37, anno: 1998,
pagine: 49 - 56
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTORS; EMISSION TOMOGRAPHY; PARTIAL SEIZURES; FOCAL EPILEPSY; IOMAZENIL; IODINE-123-IOMAZENIL; LIGAND; MRI; PET;
Keywords:
I-123 IOMAZENIL; EPILEPSY; BENZODIAZEPINE RECEPTOR; COMPARTMENT MODEL ANALYSIS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
S. Venz et al., "QUANTITATIVE ESTIMATION OF I-123 IOMAZENIL RECEPTOR-BINDING IN TEMPORAL-LOBE EPILEPSIES USING 2 SPECT ACQUISITIONS - COMPARISON WITH THE REGIONAL CEREBRAL BLOOD-FLOW AND A COMPARTMENT MODEL", Nuklearmedizin, 37(2), 1998, pp. 49-56

Abstract

Aim: To compare published fractional rare constants of I-123-lomazenil (IMZ) and C-ll-Flumazenil (three-compartment/four-parameter model) with a I-123-lomazenil receptor index calculated from two SPECT acquisitions and to compare the receptor index of the epileptogenic area withthe contralateral side in patients with unilateral temporal lobe epilepsies. Methods: 28 patients were studied. 13/28 patients had a drug-resistant unilateral temporal lobe epilepsy with a successful focus localisation performed by an extensive video/EEG monitoring. 15 other patients with clinically suspected focal epilepsy and a normal MRI and IMZ SPECT scanning were used as controls. SPECT scanning was performed in all patients 15 and 100 min after intravenous injection of 111 MBq IMZ and 10 min after application of 740 MBq Tc-99m-HMPAO. Quantification of the regional uptake was performed using ROI-technique and the specific and non-specific binding of IMZ was calculated. The receptor index was calculated by the difference of the specific binding from 15 to100 min p.i. divided by the time interval. Results: The receptor index showed a linear correlation with recently published fractional rate constants k(3) (I = 0.69 and 0.67; p = 0.15) and a moderate correlation with the k,constant (-0.53 and -0.43; p = 0,28) by the means of C-11-flumazenil PET and I-123-lomazenil SPECT studies, respectively. However, statistical significance was not reached due to the few data points available from the published reports. Furthermore, the IMZ receptor index was lower in the epilep togenic area of patients with unilateraltemporal lobe epilepsies compared with their contralateral side (p = 0.02; Wilcoxon-test). The IMZ receptor index showed a weak correlationwith the regional cerebral blood flow independent of the evaluated region (r<0.4; p<0.05). Conclusion: The IMZ receptor index indicated to be a simple routine approach to estimate the fractional rate constant k(3) (r = 0.67). The lower value of the receptor index within the epileptogenic area might be due to a lower receptor density. However in further studies, IMZ might be a helpful tool to find our subtle changes of the receptor affinity due to its approximately 30-fold higher ligand-receptor affinity compared to C-l l-Flumazenil.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:18:20