Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ASSESSMENT OF THE SAFETY AND TOLERANCE OF 6-PERCENT HYDROXYETHYL STARCH (200 0.5) SOLUTION - A RANDOMIZED, CONTROLLED EPIDEMIOLOGY STUDY/
Autore:
BOTHNER U; GEORGIEFF M; VOGT NH;
Indirizzi:
UNIV UTAH,DEPT MED INFORMAT SALT LAKE CITY UT 84132 UNIV ULM,DEPT ANESTHESIOL & INTENS CARE MED ULM GERMANY
Titolo Testata:
Anesthesia and analgesia
fascicolo: 4, volume: 86, anno: 1998,
pagine: 850 - 855
SICI:
0003-2999(1998)86:4<850:AOTSAT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAPHYLACTOID REACTIONS; PLASMA SUBSTITUTES; HEARING-LOSS; PRURITUS; DEXTRAN; THERAPY; SKIN; HES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
U. Bothner et al., "ASSESSMENT OF THE SAFETY AND TOLERANCE OF 6-PERCENT HYDROXYETHYL STARCH (200 0.5) SOLUTION - A RANDOMIZED, CONTROLLED EPIDEMIOLOGY STUDY/", Anesthesia and analgesia, 86(4), 1998, pp. 850-855

Abstract

None of the natural and synthetic colloids currently available is free from the risk of side effects. This study was performed to contribute to the epidemiology of adverse reactions of the widely used 200/0.5 hydroxyethyl starch 6% solution (HES). Study end points were anaphylactoid reactions during preanesthesia infusion and perioperative course,and pruritus 5 days postoperatively (clinical examination and inquiry) and 8 wk after application (mailed patient questionnaire). We consecutively randomized 750 patients undergoing minor elective surgery intotwo parallel groups treated with HES (from two different manufacturers) and one control group treated with lactated Ringer's solution. The study population was well matched among the groups and consisted of patients of both sexes, aged 18-95 yr, ASA physical status I-Ill. No drug-related anaphylactoid reactions were detected during either of the observation intervals. There was no episode of pruritus after the fifthpostoperative day. Incidence of pruritus after 8 wk was quite frequent but not significantly different (chi(2) test, P = 0.77): 9.1% and 12.0% in the two HES groups and 11.5% in the lactated Ringer's solution control group. Except for pruritis, we conclude that HES was associated with no more complications than lactated Ringer's solution. Implications: Anaphylactoid reactions and pruritus (itching) after the administration of a 6% hydroxyethyl starch (200/0.5) versus lactated Ringer'ssolution were assessed in a prospective, randomized, controlled study. There were no differences, although there was a more than 10% incidence of pruritus in both groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 02:03:41