Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE RELATIONSHIP OF SOLUBLE ADHESION MOLECULE CONCENTRATIONS IN SYSTEMIC AND JUGULAR VENOUS SERUM TO INJURY SEVERITY AND OUTCOME AFTER TRAUMATIC BRAIN INJURY
Autore:
MCKEATING EG; ANDREWS PJD; MASCIA L;
Indirizzi:
UNIV EDINBURGH,WESTERN GEN HOSP,DEPT ANAESTHET EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND UNIV BARI,DEPT INTENS CARE BARI ITALY
Titolo Testata:
Anesthesia and analgesia
fascicolo: 4, volume: 86, anno: 1998,
pagine: 759 - 765
SICI:
0003-2999(1998)86:4<759:TROSAM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ARTERY OCCLUSION; CLOSED-HEAD INJURY; L-SELECTIN; TNF-ALPHA; RAT-BRAIN; ISCHEMIA; ICAM-1; INTERLEUKIN-6; EXPRESSION; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Mckeating et al., "THE RELATIONSHIP OF SOLUBLE ADHESION MOLECULE CONCENTRATIONS IN SYSTEMIC AND JUGULAR VENOUS SERUM TO INJURY SEVERITY AND OUTCOME AFTER TRAUMATIC BRAIN INJURY", Anesthesia and analgesia, 86(4), 1998, pp. 759-765

Abstract

Adhesion molecules control the migration of leukocytes into tissue after injury. This may result in further cellular damage. We hypothesized that altered serum concentrations of soluble intercellular adhesion molecule (sICAM)-1 and soluble L-selectin (sL-selectin) after traumatic brain injury would correlate with injury severity and neurological outcome. We investigated serum concentrations of sICAM-1 and sl-selectin in 22 patients with traumatic brain injury admitted to the intensivecare unit. The Glasgow Coma Scale (GCS) score and Injury Severity Score were recorded. Paired arterial and jugular venous blood samples were taken on admission and 24, 48, and 96 h after injury. Mean systemic and jugular venous concentrations of sICAM-1 were normal on admission but became significantly increased by 96 h (P = 0.018). sl-selectin concentrations of injured patients were markedly below those of controlsat all time points (P < 0.001). There were no significant differencesbetween jugular venous and arterial concentrations of either sICAM-1 or sl-selectin. Serum sICAM-1 was significantly related to neurological outcome (P < 0.001) and to the GCS score (P < 0.001). These changes in adhesion molecule expression after acute brain injury may be important in the pathophysiology of secondary injury. The highly significantrelationship between serum sICAM-1 and neurological outcome suggests that the inflammatory response to injury may be detrimental. Drugs that antagonize the actions of the adhesion molecules may have a role in therapy after traumatic brain injury. Implications: This observationalstudy shows that there is a strong association between soluble intercellular adhesion molecule-1 in serum and poor neurological outcome after traumatic brain injury. This suggests that inflammation after braininjury may worsen the prognosis and that therapies directed against this inflammation may prove useful.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:16:52