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Titolo:
D1-VERSUS D2-RECEPTOR MODULATION OF VISUOSPATIAL WORKING-MEMORY IN HUMANS
Autore:
MULLER U; VONCRAMON DY; POLLMANN S;
Indirizzi:
MAX PLANCK INST COGNIT NEUROSCI,INSELSTR 22-26 D-04103 LEIPZIG GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 7, volume: 18, anno: 1998,
pagine: 2720 - 2728
SICI:
0270-6474(1998)18:7<2720:DDMOVW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-RESPONSE TASK; D1 DOPAMINE-RECEPTORS; SHORT-TERM-MEMORY; PREFRONTAL CORTEX; PARKINSONS-DISEASE; HUMAN-BRAIN; AUTORADIOGRAPHIC DISTRIBUTION; COGNITIVE PERFORMANCE; NEURONAL-ACTIVITY; CEREBRAL-CORTEX;
Keywords:
SHORT-TERM MEMORY; WORKING MEMORY; PREFRONTAL CORTEX; DOPAMINE; D1 RECEPTOR; D2 RECEPTOR; BROMOCRIPTINE; PERGOLIDE; DOMPERIDONE; PROLACTIN; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
U. Muller et al., "D1-VERSUS D2-RECEPTOR MODULATION OF VISUOSPATIAL WORKING-MEMORY IN HUMANS", The Journal of neuroscience, 18(7), 1998, pp. 2720-2728

Abstract

The effects of pergolide, a mixed D1/D2 receptor agonist, and bromocriptine, a selective D2 receptor agonist, were assessed in a visual delay task to further investigate the ''dopamine link'' of working memoryin humans and to look for differential D1 versus D2 receptor contributions. Two groups of 32 healthy young adults (16 female) received either 0.1 mg of pergolide or 2.5 mg of bromocriptine in a placebo-controlled cross-over design, A pretreatment with domperidone, a peripherallyactive D2 antagonist, was performed in both groups to reduce side effects, Interindividual differences in pharmacokinetics were controlled by the time course of serum prolactin inhibition. The working memory paradigm was a visuospatial delayed matching task; the location of a randomly generated seven-point pattern had to be memorized and compared after 2, 8, or 16 sec with a second pattern that was either identical or slightly shifted within a reference frame. The task was designed with the intention to present unique stimuli at each trial and to require minimal motor demands. Practice effects between the two pharmacological test days were minimized by training sessions that preceded the tests. The paradigm showed significant error and reaction lime increaseswith longer delays. After comparable doses, only pergolide, but not bromocriptine, facilitated visuospatial working memory performance as demonstrated by a significant drug-by-delay interaction. These findingsare in accordance with the monkey literature as well as with neuroanatomical findings, and they confirm a preferential role of prefrontal D1 receptors for working memory modulation in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:49:58