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Titolo:
DNA DUPLEXES STABILIZED BY MODIFIED MONOMER RESIDUES - SYNTHESIS AND STABILITY
Autore:
GRAHAM D; PARKINSON JA; BROWN T;
Indirizzi:
UNIV STRATHCLYDE,DEPT PURE & APPL CHEM GLASGOW G1 1XL LANARK SCOTLAND UNIV EDINBURGH,DEPT CHEM EDINBURGH EH9 3JJ MIDLOTHIAN SCOTLAND UNIV SOUTHAMPTON,DEPT CHEM SOUTHAMPTON SO16 7PX HANTS ENGLAND
Titolo Testata:
Journal of the Chemical Society. Perkin transactions. I
fascicolo: 6, , anno: 1998,
pagine: 1131 - 1138
SICI:
0300-922X(1998):6<1131:DDSBMM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED PYRIMIDINE NUCLEOSIDES; ACID RELATED-COMPOUNDS; ANTIVIRAL ACTIVITY; OLIGONUCLEOTIDES; OLIGODEOXYNUCLEOTIDES; 2'-DEOXYURIDINE; DERIVATIVES; AGENTS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D. Graham et al., "DNA DUPLEXES STABILIZED BY MODIFIED MONOMER RESIDUES - SYNTHESIS AND STABILITY", Journal of the Chemical Society. Perkin transactions. I, (6), 1998, pp. 1131-1138

Abstract

The synthesis of a series of 2'-deoxyuridine analogues modified at the 5-position and a series of 2'-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residues in length that containthese modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2'-deoxyuridine is found to impart the greatest increase in stability on the DNA duplexes studied. Thermodynamic analyses show that the reason for this increase instability arises from a decrease in enthalpy which is related to the DNA base stacking process. We suggest that the degree of stabilisationimparted by the propyne moiety may be sequence dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:09:40