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Titolo:
SURGICAL ASPECT OF ENTEROINSULAR AXIS AFTER GASTROINTESTINAL SURGERY WITH REFERENCE TO INCRETIN SECRETION
Autore:
NAITO H; SASAKI I; MATSUNO S;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT SURG 1,AOBA KU,1-1 SEIYO CHO SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Pancreas
fascicolo: 3, volume: 16, anno: 1998,
pagine: 370 - 378
SICI:
0885-3177(1998)16:3<370:SAOEAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; INSULINOTROPIC ACTION; HUMAN GLICENTIN; ORAL GLUCOSE; 7-36 AMIDE; RELEASE; GLP-1; RAT; STIMULATION;
Keywords:
ENTEROINSULAR AXIS; GASTROINTESTINAL SURGERY; LATE DUMPING SYNDROME; PROCTOCOLECTOMY; INCRETIN; PANCREATICOBILIARY DIVERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
H. Naito et al., "SURGICAL ASPECT OF ENTEROINSULAR AXIS AFTER GASTROINTESTINAL SURGERY WITH REFERENCE TO INCRETIN SECRETION", Pancreas, 16(3), 1998, pp. 370-378

Abstract

An alteration of the enteroinsular axis (EIA) may be an important etiologic factor in postsurgical changes in gastrointestinal (GI) function. In this review, we present recent works, both from our laboratory and others, on how changes in the ELA. function may be involved in postsurgical GI complications, especially late dumping syndrome (LDS). We found no or minimal direct role for vagal signals in the control of gastric inhibitory polypeptide (GIP) and enteroglucagon secretion, whichregulate EIA function. In gastrectomized patients, it is suggested that the hypersecretion of glicentin and glucagonlike peptide-1 (GLP-1) induced by a rapid arrival of nutrients to the distal gut suppresses glucagon secretion and may be a cause of LDS. In patients who underwentproctocolectomy, we observed no significant postoperative changes in EIA function, although there are some conflicting reports. It seems unlikely that ordinary pancreaticobiliary diversion would cause a significant change in ELA function after an oral glucose load. Our experimental model of ileojejunal transposition produced marked hypersecretion of incretin secreted from the distal gut, which may alter EIA function. Further elucidation of the regulatory mechanism of EIA may provide anew strategy for the medical and surgical treatment of LDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:58:42