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Titolo:
COLLAGEN-RELATED MARKERS OF BONE TURNOVER REFLECT THE SEVERITY OF LIVER FIBROSIS IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS
Autore:
GUANABENS N; PARES A; ALVAREZ L; DEOSABA MJM; MONEGAL A; PERIS P; BALLESTA AM; RODES J;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,SERV RHEUMATOL,METAB BONE DIS UNIT,C VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,LIVER UNIT E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,LAB CLIN BIOCHEM E-08036 BARCELONA SPAIN
Titolo Testata:
Journal of bone and mineral research
fascicolo: 4, volume: 13, anno: 1998,
pagine: 731 - 738
SICI:
0884-0431(1998)13:4<731:CMOBTR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT ACID-PHOSPHATASE; III PROCOLLAGEN; CROSS-LINKS; HEPATIC FIBROGENESIS; ENDOTHELIAL-CELLS; URINARY-EXCRETION; I COLLAGEN; DISEASE; RESORPTION; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
N. Guanabens et al., "COLLAGEN-RELATED MARKERS OF BONE TURNOVER REFLECT THE SEVERITY OF LIVER FIBROSIS IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS", Journal of bone and mineral research, 13(4), 1998, pp. 731-738

Abstract

The influence of a nonskeletal disease with increased connective tissue synthesis or degradation in the collagen related markers of bone turnover has been evaluated in 34 women with primary biliary cirrhosis (PBC; age range 41-81 years), a disease with increased hepatic fibrosis, often associated with osteoporosis. Serum osteocalcin (BGP), and carboxy-terminal (PICP) and amino-terminal (PINP) propeptides of type I collagen were assessed as indexes of bone formation, whereas serum tartrate-resistant acid phosphatase (TRAP), and cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), and urinary hydroxyproline (HYP), pyridinoline (PYR), deoxypyridinoline (DPYR), and type I collagen cross-linked N- (NTX) and C-telopeptide (CTX) were measured as markers of bone resorption. The histologic stage of the disease and serum amino-terminal propeptide of type III collagen (PIIINP) as an index ofliver fibrogenesis were also evaluated. BGP levels were significantlylower, whereas PICP and PINP levels were higher in patients than in controls. Among the bone resorption markers, serum ICTP and urinary PYRDPYR, HYP, NTX, and CTX levels were significantly higher in patients than in controls. Serum PIIINP levels were also increased in PBC patients. BGP did not correlate,with PICP and PINP, but these markers of bone formation as well as ICTP, PYR, DPYR and NTX correlated with serum PIIINP levels. Serum TRAP did not correlate,vith collagen-related markers of bone resorption. Moreover, patients with PIIINP and bilirubin above normal levels had higher PICP, PINP? ICTP PYR, DPYR, CTX, and NTX. These markers correlated with the histologic stage of the disease, but not with osteopenia measured by densitometric procedures in 22 patients. In conclusion, collagen-related markers of bone turnover do not reflect bone remodeling in PBC. The close association of these markers,vith PIIINP and the clinical and histologic stage of the liver disease suggests that they are influenced by liver collagen metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:39:27