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Titolo:
NEUROENDOCRINE EFFECT OF A SHORT-TERM TREATMENT WITH DHEA IN POSTMENOPAUSAL WOMEN
Autore:
RUBINO S; STOMATI M; BERSI C; CASAROSA E; LUISI M; PETRAGLIA F; GENAZZANI AR;
Indirizzi:
UNIV PISA,DEPT OBSTET & GYNECOL,VIA ROMA 55 I-56100 PISA ITALY UNIV PISA,DEPT OBSTET & GYNECOL I-56100 PISA ITALY UNIV UDINE,DEPT SURG SCI,CHAIR OBSTET & GYNECOL I-33100 UDINE ITALY CNR,ENDOCRINE RES UNIT I-56100 PISA ITALY
Titolo Testata:
Maturitas
fascicolo: 3, volume: 28, anno: 1998,
pagine: 251 - 257
SICI:
0378-5122(1998)28:3<251:NEOAST>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROEPIANDROSTERONE-SULFATE; ORAL DEHYDROEPIANDROSTERONE; GROWTH-HORMONE; BETA-ENDORPHIN; SERUM LEVELS; MALE-MICE; AGE; MEN; MORTALITY; STEROIDS;
Keywords:
DHEA; AGING; BETA-ENDORPHIN; GROWTH HORMONE; POSTMENOPAUSAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Rubino et al., "NEUROENDOCRINE EFFECT OF A SHORT-TERM TREATMENT WITH DHEA IN POSTMENOPAUSAL WOMEN", Maturitas, 28(3), 1998, pp. 251-257

Abstract

Objectives: A progressive decline of plasma dehydroepiandrosterone (DHEA) levels occurs in women during aging related to the reduction of adrenocortical secretion. A specific action of DHEA on the central nervous system (CNS) is suggested by the improvement of psychological and physical well-being in postmenopausal women after DHEA supplementation. The aim of the present study was to investigate the neuroendocrine effects of short-term DHEA supplementation in postmenopausal women: evaluating changes of plasma beta-endorphin (beta-EP) and growth hormone (GH) before and after oral DHEA (100 mg/day) for 7 days in postmenopausal women (n = 6). Methods: Before and after 7 days of DHEA supplementation, postmenopausal women underwent a neuroendocrine test with clonidine, an alpha 2 presinaptic agonist for adrenergic system (1.25 mg i.v.). Basal plasma DHEA, androstenedione (A), testosterone (T), estrone(E-1) and estradiol (E-2) levels were evaluated before and after treatment, while plasma beta-EP and GH levels were measured before and 15,30, 45, 60 and 90 min after clonidine injection. Results: Basal plasma beta-EP and GH levels did not show a significant difference before and after short-term DHEA administration, while circulating A, T, E-1 and E-2 significantly increased after treatment. The clonidine test induced a significant increase of plasma beta-EP levels in women after receiving DHEA supplementation but not before; conversely, plasma GH levels increased both before and after treatment. Conclusions: The present study indicates that short-term DHEA supplementation in postmenopausal women is able to restore the impaired response of pituitary beta-EPto clonidine, an alpha 2 presinaptic agonist. According to these datait is possible to hypothesize that DHEA could play a role in the psychological and physical well-being of postmenopausal women acting via arestoration of neuroendocrine control of antero-pituitary beta-EP secretion. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:27:43