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Titolo:
DETECTION OF EARLY GLAUCOMATOUS STRUCTURAL DAMAGE WITH CONFOCAL SCANNING LASER TOMOGRAPHY
Autore:
BATHIJA R; ZANGWILL L; BERRY C; SAMPLE PA; WEINREB RN;
Indirizzi:
UNIV CALIF SAN DIEGO,GLAUCOMA CTR,DEPT OPHTHALMOL,9500 GILMAN DR 0946LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,GLAUCOMA CTR,DEPT OPHTHALMOL LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,RES LABS,DEPT OPHTHALMOL LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,DEPT FAMILY & PREVENT MED LA JOLLA CA 92093
Titolo Testata:
Journal of glaucoma
fascicolo: 2, volume: 7, anno: 1998,
pagine: 121 - 127
SICI:
1057-0829(1998)7:2<121:DOEGSD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPTIC-NERVE HEAD; TOPOGRAPHIC MEASUREMENTS; FIELD LOSS; DISK; EYES; REPRODUCIBILITY; SIZE;
Keywords:
CONFOCAL SCANNING LASER OPHTHALMOSCOPY; EARLY GLAUCOMATOUS VISUAL FIELD LOSS; DISCRIMINANT ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
R. Bathija et al., "DETECTION OF EARLY GLAUCOMATOUS STRUCTURAL DAMAGE WITH CONFOCAL SCANNING LASER TOMOGRAPHY", Journal of glaucoma, 7(2), 1998, pp. 121-127

Abstract

Purpose: The authors determine which optic disc topographic parameters obtained by the Heidelberg Retina Tomograph (HRT, Heidelberg Engineering, Heidelberg, Germany) are most useful in detecting individuals with early glaucomatous visual field loss. Methods: Ninety-nine eyes of 49 healthy individuals and 50 age-matched individuals with early glaucomatous visual field loss were included. Three images were obtained and the mean topography image was created and used in the analyses. The HRT discriminant analysis function (software version 2.01) was appliedand compared to the Fisher linear discriminant function developed in this population. Analysis was repeated after stratifying by disc area (< 2mm(2) or 2-3 mm(2)). Results: There were statistically significantdifferences between the healthy and glaucomatous groups for all opticdisc topographic parameters (p < 0.05) measured. These differences remained after the analysis was repeated controlling for disc size, except for height variation contour. Applying the HRT discriminant function to this study population resulted in sensitivity and specificity of 62% and 94%, respectively. The sensitivity was 83% while specificity remained high (91%) for larger disc sizes. Using this data, additional discriminant functions that differentiated similarly between the two groups were: found. The best formula used cup-shape measure (third moment), rim area, height variation contour, and retinal nerve fiber layerthickness and had a sensitivity and specificity of 78% and 88%, respectively. Conclusions: Several different discriminant analysis formulasare capable of detecting early glaucomatous visual field loss in a comparable manner. The characteristics of the study population are likely to influence the discriminating power of these various formulas.

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Documento generato il 05/12/20 alle ore 02:00:34