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Titolo:
REGULATION OF SODIUM-TRANSPORT BY STEROID-HORMONES
Autore:
BONVALET JP;
Indirizzi:
UNIV PARIS 07,INSERM,U478,IFR02 CELLULES EPITHELIALES,16 RUE H HUCHARD,BP416 F-75870 PARIS FRANCE
Titolo Testata:
Kidney international
, , anno: 1998, supplemento:, 65
pagine: 49 - 56
SICI:
0085-2538(1998):<49:ROSBS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-K+-ATPASE; CORTICAL COLLECTING DUCT; 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY; MESSENGER-RNA EXPRESSION; MINERALOCORTICOID RECEPTOR; ALDOSTERONE BINDING; GENE-EXPRESSION; ALPHA-SUBUNITS; GAMMA-SUBUNITS; BETA-SUBUNITS;
Keywords:
APICAL EPITHELIAL SODIUM CHANNEL; TRANSEPITHELIAL SODIUM TRANSPORT; GLUCOCORTICOIDS; ALDOSTERONE; MINERALOCORTICOID RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Bonvalet, "REGULATION OF SODIUM-TRANSPORT BY STEROID-HORMONES", Kidney international, 1998, pp. 49-56

Abstract

The main mechanisms involved in the regulation of sodium transport bysteroid hormones are briefly reviewed. The respective roles of the apical epithelial sodium channel, which is likely to be the limitant step of steroid-regulated transepithelial sodium transport, and Na,K-ATPase are described. Regulation of these ion transporting proteins by aldosterone and glucocorticoid hormones, probably via a two step mechanism (rapid activation of channels or pumps by unknown regulators, acid modulation of the transcription/translation rate of these transporters), is discussed. The mechanisms of mineralocorticoid selectivity, that is, the integrated process allowing a specific action of aldosterone, in spite of high concentrations of glucocorticoids that crossbind withaldosterone to the mineralocorticoid receptor (MR), are explained, asis the role of the enzyme 11 beta-hydroxy-steroid dehydrogenase and the differential interactions of MR with steroid ligands and hormone responsive elements of DNA. Finally, synergism between aldosterone and antidiuretic hormone for the stimulation of sodium transport is evoked.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:36:47