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Titolo:
NEURAL EMERGENCY SYSTEM IN THE STOMACH
Autore:
HOLZER P;
Indirizzi:
GRAZ UNIV,DEPT EXPT & CLIN PHARMACOL,UNIV PL 4 A-8010 GRAZ AUSTRIA
Titolo Testata:
Gastroenterology
fascicolo: 4, volume: 114, anno: 1998,
pagine: 823 - 839
SICI:
0016-5085(1998)114:4<823:NESITS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; GASTRIC-ACID SECRETION; MUCOSAL BLOOD-FLOW; SENSITIVE SENSORY NEURONS; P-LIKE IMMUNOREACTIVITY; INTRAGASTRIC CAPSAICIN PROTECTS; AUTONOMIC NERVOUS-SYSTEM; ENDOGENOUS NITRIC-OXIDE; PERFUSED RAT STOMACH; PYLORUS-LIGATED RATS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
150
Recensione:
Indirizzi per estratti:
Citazione:
P. Holzer, "NEURAL EMERGENCY SYSTEM IN THE STOMACH", Gastroenterology, 114(4), 1998, pp. 823-839

Abstract

The maintenance of gastric mucosal integrity depends on the rapid alarm of protective mechanisms in the face of pending injury. Afferent neurons of extrinsic origin constitute an emergency system that is called into operation when the gastric mucosa is endangered by acid and other noxious chemicals. The function of these chemoceptive afferents canbe manipulated selectively and explored with the excitotoxin capsaicin. Most of the homeostatic actions of capsaicin-sensitive afferents are brought about by peptides released from their peripheral endings in the gastric wall. When stimulated, chemoceptive afferents enhance gastric blood flow and activate hyperemia-dependent and hyperemia-independent mechanisms of protection and repair. In the rodent stomach, these local regulatory roles of sensory neurons are mediated by calcitonin gene-related peptide acting via calcitonin gene-related peptide 1 receptors and neurokinin A acting via neurokinin 2 receptors, with both peptides using nitric oxide as their common messenger. In addition, capsaicin-sensitive neurons form the afferent are of autonomic reflexes that control secretory and motor functions of the stomach. The pathophysiological potential of the neural emergency system is best portrayed bythe gastric hyperemic response to acid backdiffusion, which is signaled by afferent nerve fibers. This mechanism limits damage to the surface of the mucosa and creates favorable conditions for rapid restitution and healing of the wounded mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:56:49