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Titolo:
RETINAL AXON GUIDANCE BY REGION-SPECIFIC CUES IN DIENCEPHALON
Autore:
TUTTLE R; BRAISTED JE; RICHARDS LJ; OLEARY DDM;
Indirizzi:
SALK INST BIOL STUDIES,MOL NEUROBIOL LAB,10010 N TORREY PINES RD LA JOLLA CA 92037 SALK INST BIOL STUDIES,MOL NEUROBIOL LAB LA JOLLA CA 92037
Titolo Testata:
Development
fascicolo: 5, volume: 125, anno: 1998,
pagine: 791 - 801
SICI:
0950-1991(1998)125:5<791:RAGBRC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN SULFATE PROTEOGLYCAN; RECEPTOR TYROSINE KINASES; DEVELOPMENTALLY-REGULATED EXPRESSION; LATERAL GENICULATE-NUCLEUS; CENTRAL-NERVOUS-SYSTEM; CHICK VISUAL-SYSTEM; FEMALE ALBINO-RAT; OPTIC CHIASM; NEURITE OUTGROWTH; NEURAL-TUBE;
Keywords:
CHEMOREPULSION; CHEMOATTRACTION; EPITHALAMUS; FLOOR PLATE; HYPOTHALAMUS; LATERAL GENICULATE NUCLEUS; NEUROCAN; TENASCIN; VISUAL SYSTEM DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
R. Tuttle et al., "RETINAL AXON GUIDANCE BY REGION-SPECIFIC CUES IN DIENCEPHALON", Development, 125(5), 1998, pp. 791-801

Abstract

Retinal axons show region-specific patterning along the dorsal-ventral axis of diencephalon: retinal axons grow in a compact bundle over hypothalamus, dramatically splay out over thalamus, and circumvent epithalamus as they continue toward the dorsal midbrain. In vitro, retinal axons are repulsed by substrate-bound and soluble activities in hypothalamus and epithalamus, but invade thalamus. The repulsion is mimickedby a soluble floor plate activity. Tenascin and neurocan, extracellular matrix molecules that inhibit retinal axon growth in vitro, are enriched in hypothalamus and epithalamus. Within thalamus, a stimulatory activity is specifically upregulated in target nuclei at the time thatretinal axons invade them. These findings suggest that region-specific, axon repulsive and stimulatory activities control retinal axon patterning in the embryonic diencephalon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:42:09