Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MECHANISM OF (201)THALLIUM-CHLORIDE UPTAKE IN RELATIONSHIP TO IN TUMOR-CELLS AND ITS POTASSIUM CHANNELS
Autore:
MORI K; YAMAGUCHI T; MAEDA M;
Indirizzi:
JUNTENDO UNIV,IZUNAGAOKA HOSP,DEPT NEUROSURG,1129 NAGAOKA IZUNAGAOKA SHIZUOKA 41022 JAPAN DAIICHI RADIOISOTOPE LABS LTD,RADIOPHARMACEUT & MED IMAGING RES GRP CHIBA JAPAN
Titolo Testata:
Neurological research
fascicolo: 1, volume: 20, anno: 1998,
pagine: 19 - 22
SICI:
0161-6412(1998)20:1<19:MO(UIR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TL-201 SPECT; BEARING ANIMALS; INHIBITION; VOLUME; BIODISTRIBUTIONS; DIFFERENTIATION; TRANSPORT; GRADE;
Keywords:
(201)THALLIUM-CHLORIDE; TUMOR; NA+-K+ ATPASE; NA+-K+-2CL(-) COTRANSPORTER; ATP SENSITIVE K+ CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K. Mori et al., "MECHANISM OF (201)THALLIUM-CHLORIDE UPTAKE IN RELATIONSHIP TO IN TUMOR-CELLS AND ITS POTASSIUM CHANNELS", Neurological research, 20(1), 1998, pp. 19-22

Abstract

The purpose of this study war to elucidate the mechanism of (201)Thallium-chloride (Tl-201) uptake in tumor cells and its possible relationship to potassium channels. The subcellular biodistribution of Tl-201 in tumor cells was examined in colon cancer (LS180) bearing nude mice using sequential centrifugation. The involvement of potassium channelsin Tl-201 uptake in tumor cells was examined by uptake inhibition with potassium channel blockers (ouabain, bumetanide, and glibenclamide) in cultured leukemia cells (K562). Greater than 90% of Tl-201 was found in the soluble cytoplasmic fraction. Tl-201 uptake was inhibited by ouabain and bumetanide but not by glibenclamide. These data demonstrate that Tl-201 uptake in tumor cells is mediated by the Na+-K+ ATPase and the Na+-K+-2Cl(-) cotransporter with Tl-201 acting as a potassium analogue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:50:21