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Titolo:
LONG-TERM EFFECTS OF POSTNATAL MANIPULATION ON EMOTIONALITY ARE PREVENTED BY MATERNAL ANXIOLYTIC TREATMENT IN MICE
Autore:
DAMATO FR; CABIB S; VENTURA R; ORSINI C;
Indirizzi:
CNR,IST PSICOBIOL & PSICOFARMACOL,VIALE MARX 43 I-00137 ROME ITALY UNIV ROMA LA SAPIENZA,DIPARTIMENTO PSICOL,SEZ NEUROSCI ROME ITALY
Titolo Testata:
Developmental psychobiology
fascicolo: 3, volume: 32, anno: 1998,
pagine: 225 - 234
SICI:
0012-1630(1998)32:3<225:LEOPMO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL RODENTS; RAT PUPS; BEHAVIOR; EXPOSURE; STRESS; LIFE; ULTRASOUNDS; DOPAMINE; IMMUNE; DRUGS;
Keywords:
CHLORDIAZEPOXIDE; ELEVATED PLUS MAZE; MATERNAL BEHAVIOR; MATERNAL SEPARATION; STRESS; ULTRASONIC CALLS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F.R. Damato et al., "LONG-TERM EFFECTS OF POSTNATAL MANIPULATION ON EMOTIONALITY ARE PREVENTED BY MATERNAL ANXIOLYTIC TREATMENT IN MICE", Developmental psychobiology, 32(3), 1998, pp. 225-234

Abstract

This study investigated the role of maternal behavior on the long-term effects of postnatal manipulation (15 milt of daily separation from the dam and exposure to clean bedding from Day 1 to Day 14 of postnatal life) on emotionality in the mouse. Mothers were treated with an antianxiety agent (Chlordiazepoxide: 5 mg/kg), daily upon removal of the litter from the nest. Emotionality in adult off spring was tested in the elevated plus maze. Mice manipulated during postnatal development were more explorative and less anxious than unhandled mice, but this effect was not observable in the offspring of Chlordiazepoxide-treated dams. No effect of maternal Chlordiazepoxide was observed in unhandled offspring. The pharmacological treatment of the mother did not affect either pups' ultrasonic calling during separation, or maternal behavior-far apart from the daily manipulation sessions. By contrast, Chlordiazepoxide-treated dams were less responsive toward pups upon reunion following daily separation. This alteration of dams' behavior-was not related to alterations in the amount of ultrasonic calls emitted by pups during reunion. Finally, when dams were daily injected with Chlordiazepoxide far apart from pups' removal, the pharmacological treatment was devoid of effects. These results support the view that the mother-infant inter-action which follows separation plays a major role in determining the effects of postnatal manipulations on adult emotionality. (C) 1998 John Wiley & Sons, Inc.

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Documento generato il 25/01/20 alle ore 19:41:34