Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A NEW STRATEGY FOR THE SYNTHESIS OF PHOSPHOROTHIOATES OF 2'-DEOXYRIBOLIGONUCLEOTIDES
Autore:
KUMAR P; MISRA K;
Indirizzi:
JAWAHARLAL NEHRU UNIV,CTR BIOTECHNOL,NEW MEHRAULI RD NEW DELHI 110067INDIA UNIV ALLAHABAD,DEPT CHEM ALLAHABAD UTTAR PRADESH INDIA
Titolo Testata:
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry
fascicolo: 11, volume: 36, anno: 1997,
pagine: 1000 - 1004
SICI:
0376-4699(1997)36:11<1000:ANSFTS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONICALLY INFECTED-CELLS; SOLID-PHASE SYNTHESIS; ANTIVIRAL ACTIVITY; ANALOGS; OLIGODEOXYRIBONUCLEOTIDES; OLIGODEOXYNUCLEOTIDES; INHIBITION; 1,1-DIOXIDE; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
P. Kumar e K. Misra, "A NEW STRATEGY FOR THE SYNTHESIS OF PHOSPHOROTHIOATES OF 2'-DEOXYRIBOLIGONUCLEOTIDES", Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(11), 1997, pp. 1000-1004

Abstract

2-Picoline thiol, a new reagent, has been indigenously prepared and anew strategy has been followed for the sulphurization of phosphate bond in nucleotide monomer. The 2-picolylthiophosphoro-bis-(triazolide) has been prepared using phosphite triester approach and treated with protected nucleosides to get phosphorothioate synthons. The two dimers,d(G(p)T) and d(TpT) have been synthesised in very good yields using these synthons. The removal of 2-methylpyridyl group at the end of synthesis is achieved with 1,1,3,3-tetramethylguanidinium-4-nitrobenzaldoxime in dioxane-water.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:48:09