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Titolo:
EFFECTS OF SILYMARIN IN ALCOHOLIC PATIENTS WITH CIRRHOSIS OF THE LIVER - RESULTS OF A CONTROLLED, DOUBLE-BLIND, RANDOMIZED AND MULTICENTER TRIAL
Autore:
PARES A; PLANAS R; TORRES M; CABALLERIA J; VIVER JM; ACERO D; PANES J; RIGAU J; SANTOS J; RODES J;
Indirizzi:
UNIV BARCELONA,ALCOHOL & LIVER UNITS,HOSP CLIN & PROV,C VILLARROEL,170 BARCELONA 08036 SPAIN HOSP GERMANS TRIAS & PUJOL BADALONA SPAIN HOSP LESPERIT SANT BARCELONA SPAIN HOSP MUTUA TERRASSA BARCELONA SPAIN HOSP JOSEP TRUETA GIRONA SPAIN HOSP GRANOLLERS BARCELONA SPAIN
Titolo Testata:
Journal of hepatology
fascicolo: 4, volume: 28, anno: 1998,
pagine: 615 - 621
SICI:
0168-8278(1998)28:4<615:EOSIAP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
C VIRUS-ANTIBODIES; HEPATITIS-C; LIPID-PEROXIDATION; DISEASE; RAT; INTOXICATION; ANTIOXIDANT; ASSOCIATION; MICROSOMES; PROTECTION;
Keywords:
ALCOHOLICS; ANTI-HCV ANTIBODIES; CIRRHOSIS; PROGNOSIS; SILYMARIN; SURVIVAL; TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A. Pares et al., "EFFECTS OF SILYMARIN IN ALCOHOLIC PATIENTS WITH CIRRHOSIS OF THE LIVER - RESULTS OF A CONTROLLED, DOUBLE-BLIND, RANDOMIZED AND MULTICENTER TRIAL", Journal of hepatology, 28(4), 1998, pp. 615-621

Abstract

Background/Aims: Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established, Therefore, this study was carried out to determine the effect of silymarin in alcoholics with liver cirrhosis with respect to survival and clinical and laboratory changes. Methods: From February 1986 to June 1989, we enrolled 200 alcoholics with histologically or laparoscopically proven liver cirrhosis in a randomized, double-blind multicenter trial comparing 450 mg of silymarin (150 mg/three times per day) with placebo, The primary outcome was time to death, and the secondary outcome was the progression of liver failure, Additional analyses were also performed in 75 patients in whom anti-hepatitis C virus antibodies were measured after completion of the trial. Results: One hundred and three patients were assigned to receive silymarin and 97 to receive placebo, The two groups were web matched for demographic and baseline clinical and laboratory features, A 2-year study period was completed in 125 patients (57 receiving silymarin and 68 receiving placebo), Twenty-nine patients (15 receiving silymarin, and 14receiving placebo) died during the trial, Survival was similar in patients receiving silymarin or placebo, The effect of silymarin on survival was not influenced by sex, the persistence of alcohol intake, the severity of liver dysfunction or by the presence of alcoholic hepatitis in the liver biopsy, Silymarin did not have any significant effect on the course of the disease, No relevant side-effects were observed inany group. Conclusions: The results of this study indicate that silymarin has no effect on survival and the clinical course in alcoholics with liver cirrhosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:27:01