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Titolo:
ALTERED EXPRESSION OF RET PROTOONCOGENE PRODUCT IN PROSTATIC INTRAEPITHELIAL NEOPLASIA AND PROSTATE-CANCER
Autore:
DAWSON DM; LAWRENCE EG; MACLENNAN GT; AMINI SB; KUNG HJ; ROBINSON D; RESNICK MI; KURSH ED; PRETLOW TP; PRETLOW TG;
Indirizzi:
CASE WESTERN RESERVE UNIV,INST PATHOL,MED CTR,DEPT PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,INST PATHOL,MED CTR,DEPT PATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT UROL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT BIOSTAT & EPIDEMIOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT BIOL MOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT MICROBIOL CLEVELAND OH 44106 CLEVELAND CLIN FDN,DEPT UROL CLEVELAND OH 44195
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 7, volume: 90, anno: 1998,
pagine: 519 - 523
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTOONCOGENE; CARCINOMA; RECEPTOR; KINASE; ADENOCARCINOMA; DISEASE; TISSUES; SIGNALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Dawson et al., "ALTERED EXPRESSION OF RET PROTOONCOGENE PRODUCT IN PROSTATIC INTRAEPITHELIAL NEOPLASIA AND PROSTATE-CANCER", Journal of the National Cancer Institute, 90(7), 1998, pp. 519-523

Abstract

Background: The RET proto-oncogene encodes a protein that belongs to the tyrosine kinase growth factor receptor family, Germline point mutations in RET are found in individuals with multiple endocrine neoplasia (MEN) syndromes, and gene rearrangements have been reported in papillary thyroid cancers, We recently identified transcripts of the RET proto-oncogene in human prostate cancer xenografts and prostate cancer cell lines by means of reverse transcription-polymerase chain reaction analyses, The purpose of this study was to investigate Pet protein expression in human prostate tissue, Methods: Pet protein expression was evaluated immunohistochemically in formalin-fixed, paraffin-embedded whole-prostate sections, The prostate specimens were obtained from 30 patients with prostate cancer after radical prostatectomies, Ret protein expression was compared in tumor foci and benign prostatic tissue, Medullary thyroid carcinoma tissue associated with an MEN syndrome and papillary thyroid cancer tissue served as positive controls, Results: Ret appeared to be overexpressed in high-grade (histopathologically advanced) prostatic intraepithelial neoplasia (PIN) and prostate cancer when compared with its expression level in benign prostatic secretory epithelium. In addition, there was an apparent increase in Pet proteinexpression with decreased cellular differentiation, i.e., increasing Gleason pattern, Conclusion: Expression of the RET protooncogene in benign prostatic epithelium, high-grade PIN, and histopathologically advanced prostate cancer suggests that RET may play a role in the growth of both benign and neoplastic prostate epithelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:20:00