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Titolo:
SERIAL CHANGES IN ATRIAL-NATRIURETIC-PEPTIDE AND ENDOTHELIN-1 CONCENTRATIONS - THEIR RELATIONSHIPS TO THE CARDIAC-PERFORMANCE OF PATIENTS HOSPITALIZED FOR ACUTE MYOCARDIAL-INFARCTION
Autore:
PETERSEN CL; MUNCH M; FRANDSEN E; NIELSEN JR; HESSE B; DIGEPETERSEN H;
Indirizzi:
FREDERIKSBERG UNIV HOSP,DEPT CLIN PHYSIOL & NUCL MED,NDR FASANVEJ 57 DK-2000 FREDERIKSBERG DENMARK GLOSTRUP CTY HOSP,DEPT CLIN PHYSIOL & NUCL MED GLOSTRUP DENMARK GLOSTRUP CTY HOSP,DEPT INTERNAL MED C GLOSTRUP DENMARK UNIV COPENHAGEN,RIGSHOSP DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Cardiology
fascicolo: 3, volume: 89, anno: 1998,
pagine: 210 - 215
SICI:
0008-6312(1998)89:3<210:SCIAAE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; CONGESTIVE HEART-FAILURE; RADIONUCLIDE CARDIOGRAPHY; PLASMA ENDOTHELIN-1; MORTALITY; SURVIVAL; RELEASE;
Keywords:
ACUTE MYOCARDIAL INFARCTION; ATRIAL NATRIURETIC PEPTIDE; ENDOTHELIN-1; LEFT VENTRICULAR EJECTION FRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Petersen et al., "SERIAL CHANGES IN ATRIAL-NATRIURETIC-PEPTIDE AND ENDOTHELIN-1 CONCENTRATIONS - THEIR RELATIONSHIPS TO THE CARDIAC-PERFORMANCE OF PATIENTS HOSPITALIZED FOR ACUTE MYOCARDIAL-INFARCTION", Cardiology, 89(3), 1998, pp. 210-215

Abstract

Aim: The study was designed to assess temporal changes in atrial natriuretic peptide (ANP) and endothelin-l (ET) concentrations in patientshospitalized for acute myocardial infarction (AMI) and their relationships to cardiac performance determined by radionuclide ventriculography. Patients and Methods: 20 patients with first AMI were studied. Blood samples were drawn within the first 4-18 h, after 18-24 h, and on days 2, 3 and 6. Plasma concentrations of ANP and ET were measured in blood samples taken simultaneously. Radionuclide ventriculography was performed on the day of discharge to determine left-ventricular ejection fraction (LVEF), left-ventricular end-diastolic volume index, end-systolic volume index and left-ventricular stroke volume index. Results:Median concentrations of ET decreased from 2.15 pmol/l on admission to 1.45 pmol/l at discharge (32%, p < 0.001). Median ANP rose from 29 to 79 pg/ml (172%, p < 0.001). The increment in ANP and the decrease inET concentrations from admission to discharge was inversely correlated (r = -0.81, p < 0.005). ANP was inversely correlated to LVEF (r = -0.82, p < 0.001) and to the end-systolic volume index at discharge (r =-0.73, p < 0.003). Conclusion: Dynamic and inverse fluctuations in ETand ANP occur within the Ist week of AMI. The magnitude of endocrine activation in the ANP-ET system seems to reflect an impairment in the left-ventricular systolic performance.

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Documento generato il 16/07/20 alle ore 19:57:12