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Titolo:
NEUROGENIN1 IS ESSENTIAL FOR THE DETERMINATION OF NEURONAL PRECURSORSFOR PROXIMAL CRANIAL SENSORY GANGLIA
Autore:
MA QF; CHEN ZF; BARRANTES ID; DELAPOMPA JL; ANDERSON DJ;
Indirizzi:
CALTECH,HOWARD HUGHES MED INST,DIV BIOL PASADENA CA 91125 CALTECH,HOWARD HUGHES MED INST,DIV BIOL PASADENA CA 91125 UNIV TORONTO,AMGEN INST,ONTARIO CANC INST TORONTO ON M5G 2C1 CANADA UNIV TORONTO,DEPT MED BIOPHYS TORONTO ON M5G 2C1 CANADA UNIV TORONTO,DEPT IMMUNOL TORONTO ON M5G 2C1 CANADA
Titolo Testata:
Neuron
fascicolo: 3, volume: 20, anno: 1998,
pagine: 469 - 482
SICI:
0896-6273(1998)20:3<469:NIEFTD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL NERVOUS-SYSTEM; LOOP-HELIX PROTEIN; ACHAETE-SCUTE HOMOLOG-1; PRONEURAL GENE; XENOPUS-EMBRYOS; RESTRICTED EXPRESSION; ECTODERMAL PLACODES; DROSOPHILA HOMOLOG; NEURAL DEVELOPMENT; ORGAN FORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
Q.F. Ma et al., "NEUROGENIN1 IS ESSENTIAL FOR THE DETERMINATION OF NEURONAL PRECURSORSFOR PROXIMAL CRANIAL SENSORY GANGLIA", Neuron, 20(3), 1998, pp. 469-482

Abstract

The NEUROGENINS (NGNs) are neural-specific basic helix-loop-helix (bHLH) transcription factors. Mouse embryos lacking ngn1 fail to generatethe proximal subset of cranial sensory neurons. ngn1 is required for the activation of a cascade of downstream bHLH factors, including NeuroD, MATH3, and NSCL1. ngn1 is expressed by placodal ectodermal cells and acts prior to neuroblast delamination. Moreover, NGN1 positively regulates the Delta homolog DLL1 and can be negatively regulated by Notch signaling. Thus, ngn1 functions similarly to the proneural genes in Drosophila. However, the initial pattern of ngn1 expression appears tobe Notch independent. Taken together with the fact that ectopic ngn1 expression can convert ectodermal cells to neurons in Xenopus (Ma et al., 1996), these data and those of Fode et al. (1998 [this issue of Neuron]) identify ngns as vertebrate neuronal determination genes, analogous to myoD and myf5 in myogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:06:14