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Titolo:
INTESTINAL EFFECTS OF SULFATE IN DRINKING-WATER ON NORMAL HUMAN-SUBJECTS
Autore:
HEIZER WD; SANDLER RS; SEAL E; MURRAY SC; BUSBY MG; SCHLIEBE BG; PUSEK SN;
Indirizzi:
UNIV N CAROLINA,SCH MED,DIV DIGEST DIS & NUTR,DEPT MED,CB 7080,324 BURNETT WOMACK BLDG CHAPEL HILL NC 27599 UNIV N CAROLINA,SCH MED,GEN CLIN RES CTR CHAPEL HILL NC 27599 US EPA,CTR GASTROINTESTINAL BIOL & DIS CHAPEL HILL NC 00000 US EPA,HUMAN STUDIES DIV CHAPEL HILL NC 00000
Titolo Testata:
Digestive diseases and sciences
fascicolo: 5, volume: 42, anno: 1997,
pagine: 1055 - 1061
SICI:
0163-2116(1997)42:5<1055:IEOSID>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC SULFATE; PERFORMANCE; EXCRETION; DIARRHEA; ACID;
Keywords:
DIARRHEA; SULFATE; DRINKING WATER; NORMAL ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W.D. Heizer et al., "INTESTINAL EFFECTS OF SULFATE IN DRINKING-WATER ON NORMAL HUMAN-SUBJECTS", Digestive diseases and sciences, 42(5), 1997, pp. 1055-1061

Abstract

Uncontrolled observations implicate sulfate in drinking water at concentrations exceeding 500-700 mg/liter as a cause of diarrhea, but controlled studies have not been reported. We conducted a controlled studyin normal adults to determine the effect of various drinking water sodium sulfate concentrations on bowel function. Ten healthy subjects were given a constant diet and fluid intake. Fluid consisted of 36 ml/kg/day of drinking water of various known sulfate concentrations and 500ml of other fluid. In a dose-ranging study, four subjects received drinking water with sulfate concentrations of 0, 400, 600, 800, 1000, and 1200 mg/liters for six consecutive two-day periods. In a single-dosestudy, six other subjects received water with sulfate concentrations of 0 and 1200 mg/liter for two consecutive six-day periods. Stool mass, frequency, and consistency and mouth-to-anus appearance time of colored markers were measured. In the dose-ranging study, the only significant linear trend was decreasing mouth-to-anus appearance time with increasing sulfate concentrations. In the single-dose study, 1200 mg/liter sulfate caused a significant but clinically mild increase in mean stool mass per six-day pool from 621 g to 922 g (P = 0.03). When all 10subjects were used to compare effects of 0 mg/liter and 1200 mg/litersulfate, significant differences in stool consistency (P = 0.02) and transit time (P = 0.03) were observed. None of the subjects reported diarrhea or passed more than three stools per day. In 10 normal adult subjects, sulfate in drinking water at a concentration of 1200 mg/liter, which is higher than reported to occur in US municipal water sources, caused a measurable but clinically insignificant increase in stool mass and decrease in stool consistency and appearance time, but no change in stool frequency and no complaint of diarrhea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:23:36