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Titolo:
COMPARATIVE EFFECTS OF CHROMIUM, VANADIUM AND GYMNEMA-SYLVESTRE ON SUGAR-INDUCED BLOOD-PRESSURE ELEVATIONS IN SHR
Autore:
PREUSS HG; JARRELL ST; SCHECKENBACH R; LIEBERMAN S; ANDERSON RA;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT MED,BLDG D,ROOM 371,4000 RESERVOIR RD NWWASHINGTON DC 20007 INST BIOMOL NUTR EUGENE OR 00000 USDA ARS,BELTSVILLE HUMAN NUTR RES CTR BELTSVILLE MD 00000
Titolo Testata:
Journal of the American College of Nutrition
fascicolo: 2, volume: 17, anno: 1998,
pagine: 116 - 123
SICI:
0731-5724(1998)17:2<116:CEOCVA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; FRUCTOSE-INDUCED HYPERTENSION; DEPENDENT DIABETES-MELLITUS; INDUCED INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ASCORBIC-ACID; LEAF EXTRACT; VITAMIN-C; HYPERINSULINEMIA; BIS(MALTOLATO)OXOVANADIUM(IV);
Keywords:
HYPERTENSION, SUCROSE-INDUCED; CHROMIUM POLYNICOTINATE, EFFECTS ON BP; BIS(MALTOLATO)OXOVANADIUM, EFFECTS ON BP; GYMNEMA SYLVESTRE, EFFECTS ON BP; TEARS, CHROMIUM EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H.G. Preuss et al., "COMPARATIVE EFFECTS OF CHROMIUM, VANADIUM AND GYMNEMA-SYLVESTRE ON SUGAR-INDUCED BLOOD-PRESSURE ELEVATIONS IN SHR", Journal of the American College of Nutrition, 17(2), 1998, pp. 116-123

Abstract

Objective: Effects on systolic blood pressure (SEP) of ingesting three agents reported to influence insulin metabolism, i.e., chromium polynicotinate, bis(maltolato)oxovanadium (BMOV), and the herb, Gymnema sylvestre, were assessed simultaneously in spontaneously hypertensive rats (SHR). Methods: In the first study, SHR were fed either a starch, sugar, or sugar diet containing chromium polynicotinate, bis(maltolato)oxovanadium (BMOV), or G. sylvestre. Tail SEP was estimated indirectlyand various blood chemistries were measured. TEARS formation was determined in hepatic and renal tissue. In a second study, tail SEP was measured in SHR ingesting diets containing different concentrations of BMOV. Results: Compared to starch, SHR consuming sucrose showed a significant elevation of SEP within days that was maintained for the duration of study. Addition of chromium polynicotinate to the sucrose diet at the beginning of study prevented the sucrose-induced elevation of SEP for 2 weeks, but SEP rose significantly after that. BMOV at high concentrations overcame the sucrose-induced rise in SEP and even decreased SEP below values seen in SHR eating the starch diet, but marked weight loss was noted. A second study examined different concentrations ofBMOV. At 0.01% w/w concentration of BMOV, SEP was still significantlydecreased, even though SHR did not lose body weight (BW) early on. SHR consuming G. sylvestre showed no change or even elevated SEP. Hepatic thiobarbituric acid reacting substances (TEARS) formation, an estimate of lipid peroxidation, was decreased by chromium polynicotinate andBMOV, and renal TEARS by chromium polynicotinate. Circulating cholesterol concentrations were decreased in the SHR consuming G. sylvestre. Conclusions: Chromium decreases the portion of SEP elevated by high sucrose intake as shown previously, but high levels of sucrose ingestioncan eventually overcome this. BMOV overcame sucrose-induced elevationof SEP as well as some of the ''genetic hypertension. '' Different from chromium, this decrease was not overcome by high levels of dietary sucrose. The significant lowering of cholesterol with G. sylvestre ingestion indicates some effect on metabolism, but G. sylvestre did not lower and even raised SEP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:19:18