Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARISON OF ANESTHETIC AND NON-ANESTHETIC EFFECTS ON DEPOLARIZATION-EVOKED GLUTAMATE AND GABA RELEASE FROM MOUSE CEREBROCORTICAL SLICES
Autore:
LIACHENKO S; TANG P; SOMOGYI GT; XU Y;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAESTHESIOL & CRIT CARE MED,W-1358 BIOMED SCI TOWER PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ANAESTHESIOL & CRIT CARE MED PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT PHARMACOL PITTSBURGH PA 15261
Titolo Testata:
British Journal of Pharmacology
fascicolo: 6, volume: 123, anno: 1998,
pagine: 1274 - 1280
SICI:
0007-1188(1998)123:6<1274:COAANE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEYER-OVERTON HYPOTHESIS; VOLATILE ANESTHETICS; GENERAL-ANESTHESIA; STRIATAL SYNAPTOSOMES; CELLULAR MECHANISMS; BRAIN-SLICES; RAT-BRAIN; ISOFLURANE; ACID; CURRENTS;
Keywords:
NEUROTRANSMITTER; GAMMA-AMINOBUTYRIC ACID (GABA); GLUTAMATE; GENERAL ANESTHETIC; 1-CHLORO-1,2,2-TRIFLUOROCYCLOBUTANE (F3); NON-ANESTHETIC; 1,2-DICHLOROHEXAFLUOROCYCLOBUTANE (F6); BRAIN SLICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
S. Liachenko et al., "COMPARISON OF ANESTHETIC AND NON-ANESTHETIC EFFECTS ON DEPOLARIZATION-EVOKED GLUTAMATE AND GABA RELEASE FROM MOUSE CEREBROCORTICAL SLICES", British Journal of Pharmacology, 123(6), 1998, pp. 1274-1280

Abstract

1 Investigation with substances that are similar in structure, but different in anaesthetic properties, may lead to further understanding of the mechanisms of general anaesthesia. 2 We have studied the effectsof two cyclobutane derivatives, the anaesthetic, 1-chloro-1,2,2-trifluorocyclobutane (F3), and the non-anaesthetic, 1,2-dichlorohexafluorocyclobutane (F6), on K+-evoked glutamate and gamma-aminobutyric acid (GABA) release from isolated, superfused, cerebrocortical slices from mice, by use of h.p.l.c. with fluorescence detection for quantitative analysis. 3 At clinically relevant concentrations, the anaesthetic, F3, inhibited 40 mM K+-evoked glutamate and GABA release by 72% and 47%, respectively, whereas the structurally similar non-anaesthetic, F6, suppressed evoked glutamate release by 70% but had no significant effectson evoked GABA release. A second exposure to 40 mM KCl after a similar to 30 min washout of F3 or F6 showed recovery of K+-evoked release, suggesting that F3 and F6 did not cause any non-specific or irreversible changes in the brain slices. 4 Our findings suggest that suppression of excitatory neurotransmitter release may not be directly relevant to the primary action of general anaesthetics. A mechanism involving inhibitory postsynaptic action is implicated, in which a moderate suppression of depolarization-evoked GABA release by the anaesthetic may beconsistent with the enhancement of postsynaptic GABAergic activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:25:05