Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LINOMIDE BLOCKS ANGIOGENESIS BY BREAST-CARCINOMA VASCULAR ENDOTHELIALGROWTH-FACTOR TRANSFECTANTS
Autore:
ZICHE M; DONNINI S; MORBIDELLI L; PARENTI A; GASPARINI G; LEDDA F;
Indirizzi:
UNIV FLORENCE,DEPT PHARMACOL,VIALE MORGAGNI 65 I-50134 FLORENCE ITALY ST BORTOLO HOSP,DEPT ONCOL VICENZA ITALY
Titolo Testata:
British Journal of Cancer
fascicolo: 7, volume: 77, anno: 1998,
pagine: 1123 - 1129
SICI:
0007-0920(1998)77:7<1123:LBABBV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDEPENDENT PROGNOSTIC INDICATOR; RAT PROSTATIC CANCERS; TUMOR ANGIOGENESIS; QUINOLINE-3-CARBOXAMIDE LINOMIDE; T-CELL; IMMUNOMODULATOR; METASTASIS; EXPRESSION; MELANOMA; DISEASE;
Keywords:
LINOMIDE; ANGIOGENESIS; VASCULAR ENDOTHELIAL GROWTH FACTOR; BREAST CARCINOMA; ENDOTHELIAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Ziche et al., "LINOMIDE BLOCKS ANGIOGENESIS BY BREAST-CARCINOMA VASCULAR ENDOTHELIALGROWTH-FACTOR TRANSFECTANTS", British Journal of Cancer, 77(7), 1998, pp. 1123-1129

Abstract

The blocking of angiogenesis provides a novel therapeutic target to inhibit tumour spreading. In this study, we investigated the effect of linomide on angiogenesis induced in vivo by highly angiogenic breast carcinoma cells. The rabbit cornea was used to assess neovascular growth in the absence of a tumour mass. MCF-7 cells stably transfected withthe cDNA encoding for vascular endothelial growth factor 121 (VEGF(121)) (V12 clone) were used to elicit a potent VEGF-dependent corneal angiogenesis. After tumour cell implant, albino rabbits received 100 mg kg(-1) day(-1) linomide for 5 consecutive days. Daily observation of neovascular progression indicated that linomide blocked angiogenesis. The antiangiogenic effect of linomide was apparent within 48 h from thebeginning of the treatment and was both angiosuppressive and angiostatic. The block of neovascular growth lasted over 10 days from treatment suspension, and preformed vessels, which had regressed, remained dormant, suggesting the persistence of unfavourable conditions for capillary progression. Linomide (50-200 mu g ml(-1)) was not cytotoxic in vitro on resting capillary endothelial cells but blocked endothelial cell replication induced by VEGF. Our data indicate that linomide can efficiently and persistently block VEGF-dependent angiogenesis in vivo inthe absence of a growing tumour mass. These data suggest that linomide could be a chemopreventive drug in breast cancer patients and a valuable tool in clinical settings in which metastatic spreading occurs inthe absence of a detectable tumour mass.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:42:30