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Titolo:
SUBICULAR EFFERENTS ARE ORGANIZED MOSTLY AS PARALLEL PROJECTIONS - A DOUBLE-LABELING, RETROGRADE-TRACING STUDY IN THE RAT
Autore:
NABER PA; WITTER MP;
Indirizzi:
FREE UNIV AMSTERDAM,FAC MED,DEPT ANAT & EMBRYOL,INST NEUROSCI,GRAD SCH NEUROSCI AMSTERDAM NL-1081 BT AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 393, anno: 1998,
pagine: 284 - 297
SICI:
0021-9967(1998)393:3<284:SEAOMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-REUNIENS-THALAMI; CA1 PYRAMIDAL NEURONS; ENTORHINAL CORTEX; HIPPOCAMPAL EFFERENTS; CEREBRAL-CORTEX; GUINEA-PIG; FIELD CA1; IN-VITRO; CONNECTIONS; REGION;
Keywords:
LEARNING; MEMORY; HIPPOCAMPAL FORMATION; AXON COLLATERALS; SUBICULUM; INFORMATION STORAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Naber e M.P. Witter, "SUBICULAR EFFERENTS ARE ORGANIZED MOSTLY AS PARALLEL PROJECTIONS - A DOUBLE-LABELING, RETROGRADE-TRACING STUDY IN THE RAT", Journal of comparative neurology, 393(3), 1998, pp. 284-297

Abstract

To understand the functional relevance of the subiculum as a major distributor of hippocampally processed information, detailed informationabout its neuronal organization is necessary. A striking feature of the subiculum is that it can be divided into four different areas, eachcharacterized by a specific set of efferent connections. To establishwhether the different areas of the subiculum are similar with respectto the organization of the origin of their respective efferents, the double-fluorescence retrograde-tracing technique was used to study thedegree of collateralization. Because CA1 gives rise to a major input to the subiculum but also projects to some of the targets reached by subicular projections, we compared the subicular degree of collateralization with that of CA1. Throughout CA1, the percentages of double-labeled cells were high, ranging from 17% to 39%. In contrast, the percentages of double-labeled cells in the subiculum were much lower, rangingfrom 0% to 12%, and no differences were noted between the four areas of the subiculum. This indicates that the four regions of the subiculum are organized in the same way with regard to the output connectivity. Because all four different regions of the subiculum share this paucity of collateralized projections, we conclude that subicular outputs generally originate as parallel projections. This characteristic organization is in line with a proposed function of the subiculum in information storage. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:20:45