Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
JAK-STAT PATHWAY IS INVOLVED IN THE INDUCTION OF TNF-BETA GENE DURINGSTIMULATION BY IL-2
Autore:
LU LR; ZHU JF; ZHENG ZC; YAN MD; XU WJ; SUN LY; THEZE J; LIU XY;
Indirizzi:
CHINESE ACAD SCI,SHANGHAI INST BIOCHEM,320 YUE YANG RD SHANGHAI 200031 PEOPLES R CHINA CHINESE ACAD SCI,SHANGHAI INST BIOCHEM SHANGHAI 200031 PEOPLES R CHINA INST PASTEUR PARIS FRANCE
Titolo Testata:
European Journal of Immunology
fascicolo: 3, volume: 28, anno: 1998,
pagine: 805 - 810
SICI:
0014-2980(1998)28:3<805:JPIIIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; MAMMALIAN-CELLS; INTERLEUKIN-3; EXPRESSION; RECEPTOR; ERYTHROPOIETIN; PROLIFERATION; SUPPRESSION; SIGNALS;
Keywords:
IL-2; TNF-BETA GENE; JAK-STAT PATHWAY; SIGNAL TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
L.R. Lu et al., "JAK-STAT PATHWAY IS INVOLVED IN THE INDUCTION OF TNF-BETA GENE DURINGSTIMULATION BY IL-2", European Journal of Immunology, 28(3), 1998, pp. 805-810

Abstract

IL-2 is the major regulatory cytokine of the immune system. It plays a key role in T cell survival, growth and activation. IL-2 may induce the expression of multiple genes including some cytokine genes. The induction of these genes is triggered by different signal pathways, one of them being the Jak-STAT signal pathway. The genes regulated by thispathway remain to be determined. By studying IL-2-inducible genes, wehave confirmed that the TNF-beta gene is one of the immediate early genes activated by IL-2. By analysis of the DNA sequences around 180-300 bases upstream of the transcription initiation point of the mouse TNF-beta gene, we demonstrate that there is a STAT5 binding site which is essential to the inducibility of the TNF-beta gene. Furthermore, in BA/F3 cells co-transfected with the STAT5A gene and IL-2R beta gene, the activation of the TNF-B gene promoter by IL-2 was greatly promoted,whereas the TNF-beta gene promoter became IL-2-non-inducible if the STAT5A gene was substituted with a dominant negative STAT5A, i.e. a C-terminally truncated mutant. Taken together, our results show that the Jak-STAT signal pathway is involved in induction of the TNF-beta gene in cells stimulated by IL-2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:37:56