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Titolo:
ELEVATED CIRCULATING LEVELS OF C-C CHEMOKINES IN PATIENTS WITH CONGESTIVE-HEART-FAILURE
Autore:
AUKRUST P; UELAND T; MULLER F; ANDREASSEN AK; NORDOY I; AAS H; KJEKSHUS J; SIMONSEN S; FROLAND SS; GULLESTAD L;
Indirizzi:
UNIV OSLO,RIKSHOSP,DEPT MED A,SECT CLIN IMMUNOL & INFECT DIS N-0027 OSLO NORWAY UNIV OSLO,RIKSHOSP,DEPT MED A,INTERNAL MED RES INST N-0027 OSLO NORWAY UNIV OSLO,RIKSHOSP,DEPT MED B,CARDIOL SECT N-0027 OSLO NORWAY
Titolo Testata:
Circulation
fascicolo: 12, volume: 97, anno: 1998,
pagine: 1136 - 1143
SICI:
0009-7322(1998)97:12<1136:ECLOCC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOTACTIC PROTEIN-1; CORONARY-ARTERY DISEASE; NECROSIS-FACTOR-ALPHA; HIV-INFECTION; CYTOKINES; RANTES; INFLAMMATION; EXPRESSION; CELLS;
Keywords:
HEART FAILURE; CORONARY DISEASE; CHEMOKINES; FREE RADICALS; MONOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Aukrust et al., "ELEVATED CIRCULATING LEVELS OF C-C CHEMOKINES IN PATIENTS WITH CONGESTIVE-HEART-FAILURE", Circulation, 97(12), 1998, pp. 1136-1143

Abstract

Background - Immunologic and inflammatory responses appear to play a pathogenic role in the development of congestive heart failure (CHF). Activation and migration of leukocytes to areas of inflammation are important factors in these immunologic responses. Because the C-C chemokines are potent chemoattractants of monocytes and lymphocytes and can modulate other functions of these cells (e.g. generation of reactive oxygen species), we measured circulating levels of three C-C chemokinesin CHF. Methods and Results - Levels of macrophage chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-let (MIP-1 alpha), and RANTES (regulated on activation normally T-cell expressed and secreted) were measured by enzyme immunoassays in 44 patients with CHF and 21 healthy control subjects. CHF patients had significantly elevated levels of all chemokines with the highest levels in New York Heart Association class IV, and MCP-1 and MIP-1 alpha levels were significantly inversely correlated with left ventricular ejection fraction, Elevated C-C chemokine levels were found independent of the cause of the heart failure, but MCP-1 levels were particularly raised in patients with coronary artery disease, Studies on cells isolated from peripheral bloodsuggested that platelets, CD3+ lymphocytes, and in particular, monocytes, might contribute to the elevated C-C chemokine levels in CHF. Theincreased MCP-1 levels in CHF were correlated with increased monocyteactivity reflected in an enhancing effect of serum from CHF patients on O-2(-) generation in monocytes, which was inhibited by neutralizingantibodies against MCP-1. Conclusions - This first demonstration of increased circulating levels of C-C chemokines in CHF with particularlyhigh levels in patients with severe disease may represent previously unrecognized pathogenic factors in CHF.

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Documento generato il 05/12/20 alle ore 20:00:19