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Titolo:
CEREBROSPINAL-FLUID COMPLEMENT ACTIVATION IN NEUROLOGICAL DISEASES
Autore:
TRBOJEVICCEPE M; BRINAR V; PAURO M; VOGRINC Z; STAMBUK N;
Indirizzi:
UNIV ZAGREB,SCH MED,CLIN INST LAB DIAG,CLIN HOSP CTR,KISPATICEVA 12 ZAGREB 41001 CROATIA UNIV ZAGREB,SCH MED,DEPT NEUROL,CLIN HOSP CTR ZAGREB 10000 CROATIA PULA GEN HOSP PULA CROATIA RUDJER BOSKOVIC INST ZAGREB CROATIA
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 154, anno: 1998,
pagine: 173 - 181
SICI:
0022-510X(1998)154:2<173:CCAIND>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SCLEROSIS; CSF; DISORDERS; PROTEIN; CNS; C4D;
Keywords:
CEREBROSPINAL FLUID (CSF); COMPLEMENTS C(3)C, C-4; NEUROLOGICAL DISEASES; LASER NEPHELOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M. Trbojeviccepe et al., "CEREBROSPINAL-FLUID COMPLEMENT ACTIVATION IN NEUROLOGICAL DISEASES", Journal of the neurological sciences, 154(2), 1998, pp. 173-181

Abstract

Laser nephelometry (LN) is a rapid and very sensitive method for simultaneous determination of albumin, immunoglobulins, C(3)c and C-4 in diluted serum and paired cerebrospinal fluid (CSF) samples. It is very useful in routine analyses. Determination of C(3)c and C-4 covers classical as well as alternative pathways of complement activation. In CSF, they are mostly derived from and related to serum values. Under physiological conditions, the addition of intrathecal C, synthesis is likely. The incidence of complement activation within CSF is also influenced by the method of choice (native molecules, activation products and complexes, inhibitors) and the mode of interpretation of results according to the functional state of the blood-brain barrier (BBB). Calculation of indexes and the modified Reiber's graph method are valid meansof detection of complement activation within CSF. Complement activation within CSF was confirmed in 36% (111/302) of neurological patients examined; in 55% (48/87) of patients with inflammatory and demyelinating diseases, in 40% (37/94) of patients with CNS infections and complications, in 33% (4/12) of patients with motor neuron diseases, in 27% (11/40) of patients with spinal cord compression and sequelae, in 25% (8/32) of patients with neoplastic disease, and in 17% (6/37) of patients with cerebrovascular accidents. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:08:06