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Titolo:
INTRODUCTION OF A NITROXIDE GROUP ON POSITION-2 OF 9-PHENOXYACRIDINE - EASY ACCESS TO SPIN-LABELED DNA-BINDING CONJUGATES
Autore:
BELMONT P; CHAPELLE C; DEMEUNYNCK M; MICHON J; MICHON P; LHOMME J;
Indirizzi:
UNIV GRENOBLE 1,CNRS,LEDSS,BP 53 F-38041 GRENOBLE 09 FRANCE UNIV GRENOBLE 1,CNRS,LEDSS F-38041 GRENOBLE 09 FRANCE
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 6, volume: 8, anno: 1998,
pagine: 669 - 674
SICI:
0960-894X(1998)8:6<669:IOANGO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING KB-CELLS; SUBCELLULAR-DISTRIBUTION; OLIGONUCLEOTIDES; COMPLEXES; RESONANCE; LIGANDS; PROBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Belmont et al., "INTRODUCTION OF A NITROXIDE GROUP ON POSITION-2 OF 9-PHENOXYACRIDINE - EASY ACCESS TO SPIN-LABELED DNA-BINDING CONJUGATES", Bioorganic & medicinal chemistry letters, 8(6), 1998, pp. 669-674

Abstract

In the search for spin labelled intercalators of general use to construct DNA-binding conjugates, methyl-pyrrolin-3-yl)methyloxy]-9-phenoxy-acridine 5, has been prepared. This key-intermediate reacts with amines to give the corresponding labelled 9-amino substituted acridines. Comparative EPR and fluorescence measurements show that the label causes only little modification of the binding properties of acridine. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 11:08:23