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Titolo:
MAINTENANCE OF MYONUCLEAR DOMAIN SIZE IN RAT SOLEUS AFTER OVERLOAD AND GROWTH HORMONE IGF-I TREATMENT/
Autore:
MCCALL GE; ALLEN DL; LINDERMAN JK; GRINDELAND RE; ROY RR; MUKKU VR; EDGERTON VR;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PHYS SCI,621 CIRCLE DR S,2301 LIFE SCI LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90095 NASA,AMES RES CTR MOFFETT FIELD CA 94035 GENENTECH INC S SAN FRANCISCO CA 94080
Titolo Testata:
Journal of applied physiology
fascicolo: 4, volume: 84, anno: 1998,
pagine: 1407 - 1412
SICI:
8750-7587(1998)84:4<1407:MOMDSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLICATION-STIMULATING ACTIVITY; SATELLITE CELL-PROLIFERATION; SKELETAL-MUSCLE FIBERS; IGF-I; COMPENSATORY HYPERTROPHY; PROTEIN-SYNTHESIS; GENE-EXPRESSION; SUSPENDED RATS; INSULIN; EXERCISE;
Keywords:
COMPENSATORY HYPERTROPHY; SATELLITE CELLS; SYNERGIST ABLATION; GROWTH FACTORS; MYONUCLEAR NUMBER; FUNCTIONAL OVERLOAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Mccall et al., "MAINTENANCE OF MYONUCLEAR DOMAIN SIZE IN RAT SOLEUS AFTER OVERLOAD AND GROWTH HORMONE IGF-I TREATMENT/", Journal of applied physiology, 84(4), 1998, pp. 1407-1412

Abstract

The purpose of this study was to determine the effects of functional overload (FO) combined with growth hormone/insulin-like growth factor I (GH/IGF-I) administration on myonuclear number and domain size in rat soleus muscle fibers. Adult female rats underwent bilateral ablationof the plantaris and gastrocnemius muscles and, after 7 days of recovery, were injected three times daily for 14 days with GH/IGF-I (1 mg/kg each; FO + GH/IGF-I group) or saline vehicle (FO group). Intact ratsreceiving saline vehicle served as controls (Con group). Muscle wet weight was 32% greater in the FO than in the Con group: 162 +/- 8 vs. 123 +/- 16 mg. Muscle weight in the FO + GH/IGF-I group (196 +/- 14 mg)was 59 and 21% larger than in the Con and FO groups, respectively. Mean soleus fiber cross-sectional area of the FO + GH/IGF-I group (2,826+/- 445 mu m(2)) was increased compared with the Con(2,044 +/- 108 mum(2)) and FO (2,267 +/- 301 mu m(2)) groups. The difference in fiber size between the FO and Con groups was not significant. Mean myonuclear number increased in FO (187 +/- 15 myonuclei/mm) and FO + GH/IGF-I (217 +/- 23 myonuclei/mm) rats compared with Con (155 +/- 12 myonuclei/mm) rats, although the difference between FO and FO + GH/IGF-I animalswas not significant. The mean cytoplasmic volume per myonucleus (myonuclear domain) was similar across groups. These results demonstrate that the larger mean muscle weight and fiber cross-sectional area occurred when FO was combined with GH/IGF-I administration and that myonuclear number increased concomitantly with fiber volume. Thus there appears to be some mechanism(s) that maintains the myonuclear domain when a fiber hypertrophies.

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Documento generato il 17/01/20 alle ore 20:26:21