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Titolo:
DIFFUSE LARGE B-CELL LYMPHOMA - IS MORPHOLOGIC SUBDIVISION USEFUL IN CLINICAL MANAGEMENT
Autore:
SALAR A; DESEVILLA AF; ROMAGOSA V; DOMINGOCLAROS A; GONZALEZBARCA E; PERA J; CLIMENT J; GRANENA A;
Indirizzi:
INST CATALA ONCOL,DEPT CLIN HAEMATOL,AUTOVIA CASTELLDEFELS KM 2-7 LHOSPITALET LLOBR 08907 BARCELONA SPAIN INST CATALA ONCOL,DEPT PATHOL LHOSPITALET LLOBR 08907 BARCELONA SPAIN INST CATALA ONCOL,DEPT CYTOL HAEMATOL LHOSPITALET LLOBR 08907 BARCELONA SPAIN INST CATALA ONCOL,DEPT RADIOTHERAPY LHOSPITALET LLOBR 08907 BARCELONASPAIN CIUDAD SANITARIA & UNIV BELLVITGE,HOSP PRINCIPES ESPANA BARCELONA SPAIN
Titolo Testata:
European journal of haematology
fascicolo: 3, volume: 60, anno: 1998,
pagine: 202 - 208
SICI:
0902-4441(1998)60:3<202:DLBL-I>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; EUROPEAN-AMERICAN CLASSIFICATION; T-CELL; HISTIOCYTIC LYMPHOMA; PROGNOSTIC-SIGNIFICANCE; WORKING FORMULATION; FOLLOW-UP; CHEMOTHERAPY; FEATURES; SUBCLASSIFICATION;
Keywords:
NON-HODGKINS LYMPHOMA; DIFFUSE LARGE-CELL LYMPHOMA; CENTROBLASTIC LYMPHOMA; IMMUNOBLASTIC LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A. Salar et al., "DIFFUSE LARGE B-CELL LYMPHOMA - IS MORPHOLOGIC SUBDIVISION USEFUL IN CLINICAL MANAGEMENT", European journal of haematology, 60(3), 1998, pp. 202-208

Abstract

The diffuse large B-cell lymphoma category of the REAL classificationencompasses different morphologic lymphoma subtypes in a single entity. The aim of this study is to determine the influence of the morphologic subdivision within this category with respect to clinical featuresand response to treatment. From January 1993 to October 1996, 132 patients were diagnosed de novo with diffuse large B-cell lymphoma in ourinstitution. All cases were classified according to the REAL and the Updated Kiel classifications, and immunohistochemical study was performed in all of them. Sixty-three per cent of patients received chemotherapy with a curative approach. Of the 105 assessable patients, 80 cases (74%) were classified as centroblastic (CB) and 25 cases (26%) as immunoblastic (IB), according to the updated Kiel classification. These 2 subsets of lymphomas did not differ with respect to major clinical features and laboratory parameters. Both groups had a similar complete response rate with a uniform therapeutic approach and the overall 2-yrsurvival did not show statistical differences (49% in CB vs. 45% in IB). In conclusion, for clinicians, morphologic subdivision of the diffuse large B-cell lymphoma category into CB and IB subtypes has little clinical and prognostic significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:07:20