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Titolo:
CONTRIBUTION OF ENDOTHELIN RECEPTORS IN RENAL MICROVESSELS IN ACUTE CYCLOSPORINE-MEDIATED VASOCONSTRICTION IN RATS
Autore:
CAVARAPE A; ENDLICH K; FELETTO F; PAREKH N; BARTOLI E; STEINHAUSEN M;
Indirizzi:
UNIV UDINE,DEPT INTERNAL MED,PIAZZA S MARIA MISERICORDIA 1 I-33100 UDINE ITALY UNIV HEIDELBERG,INST ANAT & CELL BIOL HEIDELBERG GERMANY UNIV HEIDELBERG,INST PHYSIOL 1 HEIDELBERG GERMANY
Titolo Testata:
Kidney international
fascicolo: 4, volume: 53, anno: 1998,
pagine: 963 - 969
SICI:
0085-2538(1998)53:4<963:COERIR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING ENDOTHELIN-1; ANTAGONISTS; KIDNEY; NEPHROTOXICITY; DYSFUNCTION; EXCRETION; ET(A); CELLS; BLOOD; FLOW;
Keywords:
ENDOTHELIN RECEPTORS; VASOCONSTRICTION; HYPERTENSION; ENDOTHELIN; BQ-123; PD 145065;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A. Cavarape et al., "CONTRIBUTION OF ENDOTHELIN RECEPTORS IN RENAL MICROVESSELS IN ACUTE CYCLOSPORINE-MEDIATED VASOCONSTRICTION IN RATS", Kidney international, 53(4), 1998, pp. 963-969

Abstract

Cyclosporine A (CsA), a widely used immunosuppressive agent, causes renal vasoconstriction and systemic hypertension. Recent data suggest that the renal ef:ect of CsA is possibly mediated by endothelin (ET). We investigated the effects of CsA on renal microvessels and the efficacy of ETA or ETA/ETB receptor antagonists in ameliorating CsA effects in the hydronephrotic rat kidney. Infusion of CsA (30 mg . kg(-1)) induced a transient increase (20%) in mean arterial pressure (MAP) and a sustained reduction (85%) in glomerular blood flow (GBF) due to preferential constriction of the arcuate artery (39%) and the proximal segment of the interlobular artery (23%). Under basal conditions the ETA receptor antagonist BQ-123 had marginal effects consisting of reduction in MAP, rise in GBF and dilation of preglomerular vessels. The Iron-selective ETA/ETB receptor antagonist PD 145065 also reduced MAP, but tended to decrease GBF and constrict large preglomerular vessels. The difference in effects of the two antagonists indicated that under basal conditions ETB blockade constricts large preglomerular vessels and reduces GBF. After BQ-123 or PD 145065,:he constriction of large preglomerular vessels and reduction in GBF induced by CsA was attenuated by about 50%: but the rise in MAP was not influenced. Our data indicate that a sizable parr of renal vasoconstriction due to CsA is mediated via ET production in large preglomerular arteries and can be avoided by the blockade of ETA receptors. Additional blockade of ETB receptors doesnot attenuate the CsA effects further, possibly because ETB receptorsmediate both vasoconstriction and dilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:43:27