Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTI-GBM GLOMERULONEPHRITIS IN MICE LACKING NITRIC-OXIDE SYNTHASE TYPE-2
Autore:
CATTELL V; COOK HT; EBRAHIM HB; WADDINGTON SN; WEI XQ; ASSMANN KJM; LIEW FY;
Indirizzi:
ST MARYS,IMPERIAL COLL,SCH MED,DEPT HISTOPATHOL,NORFOLK PL LONDON W2 1PG ENGLAND UNIV NIJMEGEN HOSP,DEPT PATHOL NIJMEGEN NETHERLANDS UNIV GLASGOW,DEPT IMMUNOL GLASGOW LANARK SCOTLAND
Titolo Testata:
Kidney international
fascicolo: 4, volume: 53, anno: 1998,
pagine: 932 - 936
SICI:
0085-2538(1998)53:4<932:AGIMLN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-COMPLEX GLOMERULONEPHRITIS; INDUCED GLOMERULAR THROMBOSIS; L-ARGININE; NEPHROTOXIC NEPHRITIS; SYNTHESIZE NITRITE; HETEROLOGOUS PHASE; RAT; EXPRESSION; LOCALIZATION; MACROPHAGES;
Keywords:
GLOMERULONEPHRITIS; NITRIC OXIDE SYNTHASE; KNOCK-OUT MICE; ALBUMINURIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
V. Cattell et al., "ANTI-GBM GLOMERULONEPHRITIS IN MICE LACKING NITRIC-OXIDE SYNTHASE TYPE-2", Kidney international, 53(4), 1998, pp. 932-936

Abstract

Nitric oxide is synthesized in experimental immune complex glomerulonephritis due lu local induction of type 2 nitric oxide synthase (NOS2). To determine the role of NOS2, the course of accelerated anti-glomerular basement membrane glomerulonephritis (anti-GEM) was examined in mice homozygous for disruption of the NOS2 gene compared with heterozygous littermates. Disease in the wild type strain (129Sv) was characterized by heavy albuminuria, glomerular neutrophil and macrophage infiltration and glomerular thrombosis. NOS2, interleukin 1B (IL-1 beta) andtumor necrosis factor alpha (TNF alpha) mRNA Isere induced by 24 hours. The NOS2-deficient mutant mice and the heterozygous mice displayed early (24 hr) and full autologous phase (day 6) injury indistinguishable from the wild-type mice. The equivalent degree of albuminuria and glomerular inflammation indicates that KOS2 does not play an essential role in this form of glomerulonephritis in the mouse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:29:10