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Titolo:
NONINVASIVE MRI EVALUATION OF CEREBRAL BLOOD-FLOW IN CEREBROVASCULAR-DISEASE
Autore:
DETRE JA; ALSOP DC; VIVES LR; MACCOTTA L; TEENER JW; RAPS EC;
Indirizzi:
UNIV PENN,DEPT NEUROL,3400 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,DEPT RADIOL PHILADELPHIA PA 19104
Titolo Testata:
Neurology
fascicolo: 3, volume: 50, anno: 1998,
pagine: 633 - 641
SICI:
0028-3878(1998)50:3<633:NMEOCB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE HUMAN STROKE; ISCHEMIC STROKE; ARTERIAL WATER; BRAIN PERFUSION; TRANSIT-TIME; INVERSION; HEMODYNAMICS; TISSUE; REACTIVITY; THRESHOLDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Detre et al., "NONINVASIVE MRI EVALUATION OF CEREBRAL BLOOD-FLOW IN CEREBROVASCULAR-DISEASE", Neurology, 50(3), 1998, pp. 633-641

Abstract

Previous studies have demonstrated that cerebral blood flow (CBF) canbe assessed noninvasively by MRI using magnetic labeling of arterial water as a diffusible flow tracer. The purpose of this study was to assess the quality of CBF images obtained from patients with cerebrovascular disease using this method, and to begin to evaluate the potentialclinical role for this technique. We recruited 14 patients who presented with stroke, TIA, or severe carotid stenosis and were likely to have altered CBF based on clinical assessment. In many of these patients, CBF imaging disclosed both focal and hemispheric hypoperfusion, either in vascular territories or in watershed regions. In 11 patients with significant proximal arterial stenosis, hemispheric CBF abnormalities localized to the side of most significant stenosis for the anterior circulation distribution. In several patients watershed hypoperfusion was even more pronounced. Our results suggest that good-quality MR CBFimages can be obtained reliably from patients with cerebrovascular disease. CBF imaging can be combined with standard structural imaging within a single MRI examination, and provides clinically meaningful information. The capability of measuring CBF easily provides a potentiallyuseful tool for clinical assessment and further investigation of stroke pathophysiology.

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Documento generato il 25/09/20 alle ore 09:57:35