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Titolo:
ANTI-HIV AGENTS - V - SYNTHESIS, STRUCTURE AND IN-VITRO ANTI-HIV ACTIVITY OF NOVEL 1H,3H-NAPHTHO[2',3' 4,5]IMIDAZO[1,2-C]THIAZOLES/
Autore:
CHIMIRRI A; GRASSO S; MONFORTE AM; MONFORTE P; RAO A; ZAPPALA M; BRUNO G; NICOLO F; SCOPELLITI R;
Indirizzi:
UNIV MESSINA,DIPARTIMENTO FARMACOCHIM,VIALE ANNUNZIATA I-98168 MESSINA ITALY UNIV MESSINA,DIPARTIMENTO FARMACOCHIM I-98168 MESSINA ITALY UNIV MESSINA,DIPARTIMENTO CHIM INORGAN CHIM ANALIT & CHIM FIS I-98166MESSINA ITALY
Titolo Testata:
Il Farmaco
fascicolo: 11, volume: 52, anno: 1997,
pagine: 673 - 677
SICI:
0014-827X(1997)52:11<673:AA-V-S>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTASE INHIBITORS NNRTIS; 1H,3H-THIAZOLO)3,4-A>BENZIMIDAZOLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A. Chimirri et al., "ANTI-HIV AGENTS - V - SYNTHESIS, STRUCTURE AND IN-VITRO ANTI-HIV ACTIVITY OF NOVEL 1H,3H-NAPHTHO[2',3' 4,5]IMIDAZO[1,2-C]THIAZOLES/", Il Farmaco, 52(11), 1997, pp. 673-677

Abstract

A series of 1H,3H-naphtho[2',3':4,5]imidazo[1,2-c]thiazoles, TBZ analogues, was prepared in order to explore the influence on anti-HIV activity of the spatial requirements of the hydrophobic moiety fused to imidazothiazole system. In spite of a butterfly-like conformation evidenced by X-ray analysis of compound 4g, the results of in vitro screening suggest that the replacement of the benzene fused ring by the naphthyl moiety negatively influences the activity of analogous thiazolobenzimidazole derivatives, some of which are potent non-nucleoside HIV-I RT inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:24:54