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Titolo:
LONG-TERM FOLLOW-UP OF BONE-MINERAL DENSITY AND BONE METABOLISM IN TRANSSEXUALS TREATED WITH CROSS-SEX HORMONES
Autore:
VANKESTEREN P; LIPS P; GOOREN LJG; ASSCHEMAN H; MEGENS J;
Indirizzi:
VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT ENDOCRINOL,POB 7057 NL-1007 MB AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT ENDOCRINOL NL-1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
Clinical endocrinology
fascicolo: 3, volume: 48, anno: 1998,
pagine: 347 - 354
SICI:
0300-0664(1998)48:3<347:LFOBDA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM; X-RAY ABSORPTIOMETRY; MEN; OSTEOPOROSIS; WOMEN; ESTROGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
P. Vankesteren et al., "LONG-TERM FOLLOW-UP OF BONE-MINERAL DENSITY AND BONE METABOLISM IN TRANSSEXUALS TREATED WITH CROSS-SEX HORMONES", Clinical endocrinology, 48(3), 1998, pp. 347-354

Abstract

OBJECTIVE It is unknown whether long term cross-sex hormone treatmentaffects the human skeleton, We monitored bone mineral density and biochemical markers of bone turnover for 28-63 months in 20 male-to-female transsexuals (M --> F) treated with anti-androgens and oestrogens, and 19 female-to-male transsexuals (F --> M) treated with androgens, They underwent gonadectomy 13-35 months after the start of cross-sex hormone administration. DESIGN Bone mineral density (BMD) and the markersof bone turnover osteocalcin, alkaline phosphatase, fasting urinary calcium/creatinine and hydroxyproline/creatinine, were measured at baseline, after 1 year and after 28-63 months of cross-sex hormone administration, RESULTS In oestrogen-treated M --> F, variables of bone turnover decreased significantly with consecutive measurements, BMD had increased significantly after 1 year, but decreased again to baseline levels after 28-63 months of cross-sex hormones, In F --> M, alkaline phosphatase levels increased during the first year, BMD did not change during the first year but had decreased significantly after 28-63 monthsfollowing ovariectomy, In both M --> F and F --> M, the change of BMDcorrelated inversely with serum LH and FSH levels, Of all biochemicalvariables LH levels appeared to be the best predictor of loss of BMD;in the long-term LH levels were more elevated in testosterone-treatedF --> M than in oestrogen-treated M --> F transsexuals, CONCLUSION InM --> F, oestrogen treatment prevented bone loss after testosterone deprivation. In F --> M the testosterone dosage used, associated with adecline in serum oestradiol levels, was unable to maintain bone mass fully in all subjects in the longer term, The inverse relationship between BMD and serum LH revels suggests that the dose of hormone replacement has been too low in subjects with a decline in their BMD, Its cause might be underdosing or non-compliance in some patients. We proposethat serum LH levels may be used as a measure of the adequacy of replacement with sex steroids.

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Documento generato il 03/12/20 alle ore 14:58:56