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Titolo:
ELEVATED SERUM GRANULOCYTE-COLONY-STIMULATING FACTOR LEVELS IN PATIENTS WITH GRAVES-DISEASE
Autore:
IITAKA M; NOH JY; KITAHAMA S; FUKASAWA N; MIURA S; KAWAKAMI Y; KAWASAKI S; YAMANAKA K; ISHII J; KATAYAMA S; ITO K;
Indirizzi:
SAITAMA MED SCH,DEPT INTERNAL MED 4,38 MOROHONGO MOROYAMA SAITAMA 35004 JAPAN ITO HOSP TOKYO JAPAN
Titolo Testata:
Clinical endocrinology
fascicolo: 3, volume: 48, anno: 1998,
pagine: 275 - 280
SICI:
0300-0664(1998)48:3<275:ESGFLI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED AGRANULOCYTOSIS; G-CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M. Iitaka et al., "ELEVATED SERUM GRANULOCYTE-COLONY-STIMULATING FACTOR LEVELS IN PATIENTS WITH GRAVES-DISEASE", Clinical endocrinology, 48(3), 1998, pp. 275-280

Abstract

OBJECTIVE Agranulocytosis is a serious side effect of anti-thyroid drugs (ATD), Granulocyte colony-stimulating factor (G-CSF) is one of thecytokines that increase granulocyte number. The aim of this study wasto examine the sequential variation of serum G-CSF levels in patientswith Graves' disease before and after ATD therapy, PATIENTS Sixty-three patients with Graves' disease were studied before, during and aftertreatment with methimazole (MMI). Serum samples from 71 healthy subjects were used as controls, DESIGN AND MEASUREMENTS Serum levels of G-CSF were measured by a never chemiluminescent enzyme immunoassay, whichwas sensitive enough to determine G-CSF levels in healthy subjects, Blood granulocyte counts, serum, thyroid hormone and TSH levels, and titres of thyroid autoantibodies were also measured, RESULTS Serum G-CSFlevels in Graves' patients before and 2 weeks after MMI were significantly higher than in healthy subjects, There was a significant correlation between serum G-CSF levels and granulocyte counts in untreated patients with Graves' disease. Untreated patients with granulocyte counts less than 2x10(9)/l had significantly lower serum G-CSF levels as compared with other untreated patients, Serum G-CSF levels gradually decreased thereafter. No correlation was observed between serum G-CSF levels and serum thyroid hormone levels or titres of thyroid autoantibodies. After ATD treatment, no correlation was found between serum G-CSF levels and granulocytes counts. There was no significant correlation between the change of serum G-CSF levels and that of granulocyte countsbefore and after MMI treatment. Graves' patients with mild agranulocytosis had normal or elevated serum G-CSF levels, CONCLUSIONS Significantly elevated serum G-CSF levels were observed in patients with Graves' hyperthyroidism. During ATD therapy, deficiency of G-CSF was not identified as a cause of agranulocytosis in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:09:05