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Titolo:
QUANTITATIVE MEASUREMENTS OF CEREBRAL BLOOD-FLOW IN RATS USING THE FAIR TECHNIQUE - CORRELATION WITH PREVIOUS IODOANTIPYRINE AUTORADIOGRAPHIC STUDIES
Autore:
TSEKOS NV; ZHANG FY; MERKLE H; NAGAYAMA M; IADECOLA C; KIM SG;
Indirizzi:
UNIV MINNESOTA,CMRR,SCH MED,DEPT RADIOL,385 E RIVER RD MINNEAPOLIS MN55455 UNIV MINNESOTA,CMRR,SCH MED,DEPT RADIOL MINNEAPOLIS MN 55455 UNIV MINNESOTA,SCH MED,DEPT NEUROL MINNEAPOLIS MN 55455
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 4, volume: 39, anno: 1998,
pagine: 564 - 573
SICI:
0740-3194(1998)39:4<564:QMOCBI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE; ARTERIAL WATER; BRAIN PERFUSION; INVERSION; RECOVERY; SPINS; TRANSIT; DAMAGE;
Keywords:
CEREBRAL BLOOD FLOW; PERFUSION; HYPERCAPNIA; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N.V. Tsekos et al., "QUANTITATIVE MEASUREMENTS OF CEREBRAL BLOOD-FLOW IN RATS USING THE FAIR TECHNIQUE - CORRELATION WITH PREVIOUS IODOANTIPYRINE AUTORADIOGRAPHIC STUDIES", Magnetic resonance in medicine, 39(4), 1998, pp. 564-573

Abstract

Flow-sensitive alternating inversion recovery (FAIR) is a recently introduced MRI technique for assessment of perfusion that uses blood water as an endogenous contrast agent. To characterize the FAIR signal dependency on spin tagging time (inversion time (TI)) and to validate FAIR for cerebral blood flow (CBF) quantification, studies were conducted on the rat brain at 9.4 T using a conventional gradient-recalled echo sequence. The T-1 of cerebral cortex and blood was found to be 1.9 and 2.2 s, respectively, and was used for CBF calculations. At short TIs (<0.8 s), the FAIR signal originates largely from vascular components with fast flows, resulting in an overestimation of CBF. For TI > 1.5s, the CBF calculated from FAIR is independent of the spin tagging time, suggesting that the observed FAIR signal originates predominantly from tissue/capillary components. CBF values measured by FAIR with TI of 2.0 s were found to be in good agreement with those measured by theiodoantipyrine technique with autoradiography in rats under the same conditions of anesthesia and arterial pCO(2). The measured pCO(2) index on the parietal cortex using the FAIR technique was 6.07 ml/100 g/min per mmHg, which compares well with the pCO(2) index measured by other techniques. The FAIR technique was also able to detect the regional reduction in CBF produced by middle cerebral artery occlusion in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:05:23