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Titolo:
FLUORINE-18-FDG PET AND IODINE-123-IMT SPECT IN THE EVALUATION OF BRAIN-TUMORS
Autore:
WEBER W; BARTENSTEIN P; GROSS MW; KINZEL D; DASCHNER H; FELDMANN HJ; REIDEL G; ZIEGLER SI; LUMENTA C; MOLLS M; SCHWAIGER M;
Indirizzi:
TECH UNIV MUNICH,KLINIKUM RECHTS ISAR,DEPT NUCL MED,ISMANINGERSTR 22 D-81675 MUNICH GERMANY TECH UNIV MUNICH,KLINIKUM RECHTS ISAR,DEPT RADIAT ONCOL D-81675 MUNICH GERMANY TECH UNIV MUNICH,STADT KRANKENHAUS MUNCHEN BOGENHAUSEN,DEPT NEUROSURGD-8000 MUNICH GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 5, volume: 38, anno: 1997,
pagine: 802 - 808
SICI:
0161-5505(1997)38:5<802:FPAISI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; AMINO-ACID-TRANSPORT; F-18 FLUORODEOXYGLUCOSE; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; COMPUTED-TOMOGRAPHY; GLIOMAS; CARBON-11-METHIONINE; METHIONINE; DIAGNOSIS; BIOPSIES;
Keywords:
FLUORINE-18-FDG; IODINE-123-IMT; GLIOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
W. Weber et al., "FLUORINE-18-FDG PET AND IODINE-123-IMT SPECT IN THE EVALUATION OF BRAIN-TUMORS", The Journal of nuclear medicine, 38(5), 1997, pp. 802-808

Abstract

The high glucose utilization of normal gray matter limits the detection of brain tumor tissue by PET using F-18-fluorodeoxyglucose (FDG). The aim of this study was to evaluate whether the examination of amino acid transport with the SPECT tracer I-123-alpha-methyl-L-tyrosine (IMT) allows better identification of tumor tissue than FDG-PET, Methods:Nineteen patients (16 with gliomas, 3 with nontumorous lesions) were included in the study. Two independent observers classified PET and SPECT images as positive or negative for tumor tissue and defined the extent of tumor with regions of interest. Tracer uptake of FDG and IMT was quantified by calculating the tumor uptake relative to contralateral gray and white matter. Results: SPECT studies were interpreted concordantly in 18 patients (kappa = 0.77) and all tumors were identified by both observers. PET studies were interpreted discordantly in 4 patients (kappa = 0.52) and only 10 tumors were identified by both observers. Interobserver variability in definition of tumor extent was significantly lower in the IMT-SPECT than in the FDG-PET studies (p = 0.03). Mean tumor uptake relative to gray and while matter was 1.93 +/- 0.42 and 2.25 +/- 0.46 for IMT and 0.93 +/- 0.32 and 1.61 +/- 0.52 for FDG. All tumor uptake ratios were significantly (p < 0.01) higher for IMT than FDG, even when only glioblastomas were analyzed. No significant correlation was observed between the various uptake ratios of FDG and IMT. Conclusion: Despite the lower resolution and lower sensitivity of SPECT compared with PET, IMT-SPECT was clearly superior to FDG-PET in the detection and delineation of tumor tissue.

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Documento generato il 21/01/21 alle ore 07:18:18